Shorter degradation period in BTI stents after porcine coronary artery implantation




Background


Bioabsorbable stents (BASs) have the potential advantages of reduction of late stent thrombosis and restoration of vasomotor function after disappearing from the treated coronary sites. Recently, discernible BVS (one BAS) struts were demonstrated by histology at 2 years, and complete degradation was achieved by 3 years. In this study, BTI (one BAS) strut location, degradation, and inflammation were evaluated by histopathology over time.




Methods


A total of 31 BTI stents were implanted in porcine coronary arteries. At termination, BTI stented vessels were harvested at 1 month ( n =7), 6 months ( n =6), 12 months ( n =6), and 18 months ( n =13), respectively. The stented coronary arteries were cut into proximal, middle, and distal sections and stained with H&E and VM. Percentage of strut remnants, strut location, and inflammation were semiquantitatively scored. The percent of strut degraded was also evaluated.




Methods


A total of 31 BTI stents were implanted in porcine coronary arteries. At termination, BTI stented vessels were harvested at 1 month ( n =7), 6 months ( n =6), 12 months ( n =6), and 18 months ( n =13), respectively. The stented coronary arteries were cut into proximal, middle, and distal sections and stained with H&E and VM. Percentage of strut remnants, strut location, and inflammation were semiquantitatively scored. The percent of strut degraded was also evaluated.

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Nov 16, 2017 | Posted by in CARDIOLOGY | Comments Off on Shorter degradation period in BTI stents after porcine coronary artery implantation

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