Category
High-velocity criteria
Low-velocity criteria
Drop in ABI
I (highest risk)
PSV > 300 cm/s or Vr > 3.5
GFV < 45 cm/s
>0.15
II (high risk)
PSV > 300 cm/s or Vr > 3.5
GFV > 45 cm/s
<0.15
III (intermediate risk)
PSV 180–300 cm/s or Vr > 2.0
GFV > 45 cm/s
<0.15
IV (low risk)
PSV < 180 cm/s or Vr < 2.0
GFV > 45 cm/s
<0.15
An interesting finding in Bandyk’s series was that of lesion regression when a Category III (intermediate graft stenosis [PSV 150–300 cm/s, Vr < 3.5]) lesion is discovered in the first 3 months after surgery; it may regress (30–35%), remain stable, or progress to a high-grade stenosis (40–50%) [31]. Given the variable biological behavior, it is critical to perform serial duplex studies at 4–6-week intervals for Category III abnormalities. These lesions will usually stabilize or progress within 4–6 months [9, 42].
As suggested by the previous study from our group, abnormal duplex findings do not always mandate further therapy [1, 45]. This is especially true if the abnormal finding is moderate PSV ratio elevation near the proximal anastomosis. We speculate that the hemodynamics at vessel bifurcations, which occurs at the typical end-to-side proximal anastomosis, is not strictly comparable to flow dynamics within the graft because of size discrepancies between the graft and native artery. Possibly this turbulence and the resulting abnormalities in PSV ratios at the proximal anastomosis are less predictive of graft thrombosis than the same abnormalities at other locations.
Recommendation of Lifelong Surveillance
Clearly duplex surveillance of infrainguinal bypass grafts is beneficial, but how long does the surveillance program need to continue? Most reviews have shown a definite benefit up to 2 years based on the fact that 70–80% of all graft abnormalities develop and require revision during this time period. Erickson and co-workers recommend that surveillance continues indefinitely for autogenous bypass grafts [46]. They reported that 18% of the initial interventions for a duplex-detected lesion occurred after the initial 24-month period. Sixty-three percent of these defects occurred at an anastomosis. Although the incidence of vein graft stenosis developing decreases over time, atherosclerotic changes continue in native arteries. Another important finding to look for in older vein grafts is aneurysmal degeneration of the vein. Vein dilation is usually focal and can be associated with mural thrombus, which may warrant segmental graft revision. We support the concept of lifelong vein graft surveillance, which also gives the vascular surgeon the opportunity to monitor development of atherosclerosis in other vascular beds.
Summary
Duplex ultrasonography is the method of choice for the surveillance of infrainguinal bypass grafts. Noninvasive vascular laboratories should continuously correlate its interpretations with arteriographic findings and clinical outcomes. Any focal PSV > 300 cm/s or a PSV ratio > 3.5 between two adjacent segments is generally accepted as a strong indicator for a focal stenosis that may threaten graft patency. Low PSVs throughout the graft (<45 cm/s), as well as lack of diastolic forward flow as evidenced by loss of biphasic Doppler signals throughout the graft, may also indicate inflow or outflow problems and warrant further investigation. Arteriography and appropriate endovascular or open surgical revision of failing grafts should be judiciously implemented by the vascular surgeon to improve long-term patency and limb salvage rates.
Review Questions
- 1.
Which of the following types of bypasses does duplex ultrasound surveillance have the highest sensitivity for the diagnosis of a failing graft?
- a.
Femoral to popliteal bypass graft with PTFE
- b.
Femoral to tibial bypass graft with vein
- c.
Femoral to tibial bypass graft with PTFE
- d.
Femoral to popliteal bypass graft with vein
- a.
- 2.
What percentage of infrainguinal bypasses will develop a critical stenosis at some point during follow-up?
- a.
1%
- b.
10%
- c.
20–40%
- d.
50–60%
- e.
>60%
- a.
- 3.
Which of the following criteria is an indicative of a failing prosthetic bypass graft?
- a.
Single measurement of graft flow velocity of 150 cm/s
- b.
Biphasic signal throughout the graft
- c.
Ratio of PSVs = 2.5 at two points within the graft
- d.
Decreased PSVs < 45 cm/s throughout the graft
- e.
Triphasic Doppler graft flow
- a.
Answer Key
- 1.
b
- 2.
c
- 3.
d
References
1.
2.
Lundell A, Lindblad B, Bergqvist D, Hansen F. Femoropopliteal-crural graft patency is improved by an intensive surveillance program: a prospective randomized study. J Vasc Surg. 1995;21:26–34.
3.
4.
Rutherford RB, Baker JD, Ernst C, Johnston KW, Porter JM, Ahn S, Jones DN. Recommended standards for reports 23. Rationale and benefits of surveillance after prosthetic infrainguinal bypass grafts dealing with lower extremity ischemia: revised version. J Vasc Surg. 1997;26:517.CrossrefPubMed