In particular cases, for example, in the evaluation of LV masses or thrombi, contrast agents have been shown to improve its diagnosis. A thrombus for instance, is usually seen as a non-opacified structure. Contrast is also useful for the diagnosis of non-compaction, in which the addition of an agent allows for the myocardial layers to be clearly displayed and the ratio to be calculated (2:1 non compacted to compacted myocardium is the usual finding). Contrast can be used in the identification of complications of myocardial infarction such as LV aneurysm, pseudoaneurysm, and myocardial rupture.

CE for stress testing also yields important information, given that images tend to be worse during stress. Thus, addition of contrast provides a marked improvement in images, and increases the percentage of wall motion abnormalities visualized.