Complications of Pulmonary Resection
Benjamin E. Haithcock
Richard H. Feins
It is often said that the best way to handle a surgical complication is to avoid it. It is hoped that, knowing some of the technical and judgmental nuances of lung resections, one can avoid many intraoperative and postoperative complications. Chapters 20 and 21 cover specifically evaluation of the heart and lungs. Also, it is important to evaluate the patient’s medications and comorbidities prior to pulmonary resection.
In addition to the usual evaluation of lung, heart, and neurologic function, care must be taken to ensure adequate hemostasis in the operative and postoperative period. Specifically, disease processes such as cirrhosis and other acquired or hereditary coagulopathies must be known and managed appropriately prior to operative interventions. Patients taking aspirin, other platelet inhibitors, warfarin, or any antithrombotic agents must be identified. Aspirin and other antiplatelet agents ideally should be stopped 7 to 10 days prior to the planned procedure, but 3 days may be adequate. A bleeding time can be used to guard against ongoing platelet dysfunction after these medications are stopped. The normal range should be 2 to 9 minutes. Warfarin should be discontinued 3 to 4 days prior to pulmonary resection to ensure normalization of international normalized ratio (INR), or prothrombin time. In addition, a careful history and the activated partial thromboplastin time (aPTT) should be checked prior to commencing the procedure. Prior to planned pulmonary resection, evaluation with a cardiologist should be considered for patients with cardiac stents who are taking antiplatelet medications.
Clopidogrel (Plavix) presents a special problem. This drug has become ubiquitous since the widespread use of coronary stenting. In addition, the indications have broadened to include patients with a history of recent myocardial infarction (MI), recent stroke, or established peripheral artery disease as well as patients with non–ST-segment elevation acute coronary syndrome (unstable angina/non–Q-wave MI), including those who are to be managed medically or with percutaneous coronary intervention (with or without stent) or coronary artery bypass grafting. It is recommended that clopidogrel (75 mg/day) be given for at least 1 month after bare metal stent implantation (or a minimum of 2 weeks if the patient is at increased risk of bleeding)—ideally up to 12 months in patients with drug-eluting stents. Chapter 21 contains a detailed, well-referenced discussion of this drug, the consequences of drug cessation, and methods of managing drug substitution. Substituting a short-acting antiplatelet agent such as a small-molecule 2b3a inhibitor—i.e., eptifibatide (Integrilin), abciximab (ReoPro), or tirofiban (Aggrastat)—for clopidogrel at the time of surgery should protect the coronary artery lesion and prevent excessive bleeding.
The surgeon must also be aware of the inhibitory effects that popular herbal medications may have on the coagulation cascade. Some of these herbs include ginkgo biloba, ginseng, saw palmetto, and garlic.
Mortality and Morbidity
Mortality rates after pulmonary resection are hard to compare. This is because most older reports give only in-hospital mortality, while most current reports give 30-day mortality. Mortality following pneumonectomy varies widely depending on the experience and aggressiveness of the surgical team and includes operations on marginal patients as well as more radical resections. In considering pneumonectomy, one should keep in mind the personal observations of Ronald Ponn, from the sixth edition of this book:
First, in contrast to the laws of physics, “pneumonectomy is greater than the sum of its parts.” This implies that resection of an equal but bilateral amount of lung tissue is associated with less morbidity than the emptying of an entire pleural space. Second, pneumonectomy itself is a disease. This implies that the life of some pneumonectomy patients is saved by the procedure but often changed in its quality forever. Pneumonectomy patients remain at risk for life for certain late complications.
Table 39-1 lists the mortality rate for pneumonectomy in selected institutional series with a minimum of 200 procedures. The rates varied from 5.0% to 11.2%. For lobectomy, the mortality rates are more comparable. Table 39-2 lists the mortality rates for selected institutional series with a minimum of 1,000 procedures. These rates vary from 1.2% to 4.2%. For comparison, Table 39-3 shows the mortality following lobectomy and pneumonectomy from the voluntary Society of Thoracic Surgeons (STS) General Thoracic Database from 2008. The 30-day mortality for lobectomy was 1.5% and pneumonectomy was 5.8%.
Likewise, data on length of stay may not be comparable between countries with varying degrees of urgency for discharge. Using the STS General Thoracic Surgery Database may be the best benchmark at present. Table 39-3 shows the total and
postoperative lengths of stay for segmentectomy, lobectomy, and pneumonectomy. The postoperative length of stay varied from 6.1 days for segmentectomy to 8.3 days for pneumonectomy. The rate for lobectomy was similar to that for segmentectomy.
postoperative lengths of stay for segmentectomy, lobectomy, and pneumonectomy. The postoperative length of stay varied from 6.1 days for segmentectomy to 8.3 days for pneumonectomy. The rate for lobectomy was similar to that for segmentectomy.
Table 39-1 Mortality Rate for Pneumonectomy in Selected Institutional Series With a Minimum of 200 Procedures | |||||||||||||||||||||
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The main reason in the United States for prolonged lengths of stay after pulmonary resection beyond the management of pain and mobilization are related to postoperative complications. Table 39-4 shows the postoperative events or complications listed in the STS General Thoracic Surgery Database from 2008. By far the vast majority of problems are pulmonary, related to a variety of factors including underlying comorbidities, the extent of the operation, and postoperative pain management. A discussion of some of the specific issues and problems with pulmonary resections follows.
Intraoperative Complications
The three major life-threatening complications during the operation, other than those associated with anesthetic management (Chapters 22, 23 and 24), are nerve injury; injury to a major vessel with massive hemorrhage, cardiac arrhythmias, and myocardial ischemia (Chapter 40); and the development of a contralateral pneumothorax. Intraoperative complications that do not present an immediate threat to life but often cause significant morbidity and sometimes mortality postoperatively include injuries to an intrathoracic nerve, the thoracic duct, the esophagus, the spinal cord, or the dura.
Patient Positioning
Improper positioning of a patient undergoing lateral thoracotomy can result in intraoperative nerve damage. Therefore each area susceptible to nerve pressure should be adequately padded. The torso ideally should rest on a large gel pad or foam egg crate placed on the bed or on the “beanbag” if one is used. This is particularly important to prevent peroneal nerve injury to the dependent leg. If tape or a strap is used across the table, it should be placed between the iliac crest and the femoral head to avoid pressure injury on sensory nerves that circle around the skeleton at both points. Both the up and down arms are susceptible to nerve injury. This can occur to the ulnar nerve along the ulnar groove at the elbow, resulting in loss of sensation in the ring and small fingers or to the radial nerve along the inner aspect of the biceps, resulting in loss of dorsiflexion of the wrist. An inflated but unpadded bean bag or the post used to support the upper arm can cause these pressure complications. Most often the injuries are transient, but they can be quite troublesome for the patient. For patients undergoing median sternotomy or clamshell incisions, it is also important to properly pad the ulnar grooves bilaterally when the arms are tucked by the side. In addition, all intravenous and arterial line connectors should be tightened, the stopcocks secured, and the entire connection padded. Finally, the head must be supported and kept neutral to prevent brachial plexus stretching and injury.
Table 39-2 Mortality Rate for Lobectomy in Selected Institutional Series With a Minimum of 1,000 Procedures | ||||||||||||
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Table 39-3 Mortality and Length of Stay for Selected Procedures | ||||||||||||||||||||||||||||||||||||||
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Posterolateral Thoracotomy
All operations must begin with a surgical time out to confirm patient identity, planned procedure, and that the proper side is being operated upon. The World Health Organization has promulgated the so-called Expanded Time Out, which can include procedures to ensure the administration of prophylactic antibiotics, venous thromboembolic prophylaxis, beta blockers, and so on (Fig. 39-1). Copies may be obtained at http://www.who.int.easyaccess1.lib.cuhk.edu.hk/patientsafety/safesurgery/tools_resources/SSSL_Checklist_finalJun08.pdf. Backster2 and colleagues used a similar checklist prior to cardiac surgery. They stated “By politely challenging our surgical team as to the inclusion of these five risk-avoidance strategies in 167 consecutive patients, we increased our compliance to more than 90% for each preventive measure.”
The standard posterolateral incision is usually made 2 cm below the tip of the scapula. In some instances, particularly in obese patients, the spine of the scapula, which obliquely crosses the medial four-fifths of the dorsal surface of the scapula at its upper part and separates the supraspinatus fossa from the
infraspinatus fossa, can be mistaken for the tip. This results in an incision that is too high and across the body of the scapula. Correction must be accomplished by enlarging the incision to allow its use or by closing it and making the proper incision. Either course results in postoperative pain and impairment of shoulder mobility.
infraspinatus fossa, can be mistaken for the tip. This results in an incision that is too high and across the body of the scapula. Correction must be accomplished by enlarging the incision to allow its use or by closing it and making the proper incision. Either course results in postoperative pain and impairment of shoulder mobility.
Table 39-4 Morbidity for Selected Procedures | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Entrance into the chest should be preceded by confirmation that the lung is moving independently of the parietal pleura. This should be noted even with a lack of ventilation as long as there is no visceral and parietal pleural symphysis. Once it is confirmed, the pleura may be opened by piercing it with a firm object such as a Kelly clamp, the cold cautery tip, or the blunt end of a scalpel. Freedom along the incision should be confirmed as the pleura is further opened and the lung should be actively retracted away from the incision to prevent a parenchymal injury.
Rib spreading should be kept to the least amount compatible with a safe operation. To obtain further rib spreading, the costotransverse ligament may be divided. This ligament attaches to the nonarticular portion of the rib tubercle. Care must be taken to avoid injuring the posterior ramus branch of the segmental thoracic artery, which runs backward through a space bounded above and below by the necks of the ribs, medially by the body of a vertebra, and laterally by an anterior costotransverse ligament. It is a very important vessel because it gives off a spinal branch that enters the vertebral canal through the intervertebral foramen. Once this vessel is transected, it retracts behind the articular portion of the tubercle, which presents a
small oval surface for articulation with the end of the transverse process of the lower of the two vertebrae to which the head is connected. To expose the ramus branch, the articular tubercle may be opened. Careful cautery can be used. However, because the nerve root damage and segmental ganglion are in close proximity, neurologic injury may result. A sponge can be temporarily placed at the angle, but the surgeon must avoid packing this space, because its base is the vertebral foramen and injury to the spine is possible. Another method of control is to apply liquid hemostatic agents.
small oval surface for articulation with the end of the transverse process of the lower of the two vertebrae to which the head is connected. To expose the ramus branch, the articular tubercle may be opened. Careful cautery can be used. However, because the nerve root damage and segmental ganglion are in close proximity, neurologic injury may result. A sponge can be temporarily placed at the angle, but the surgeon must avoid packing this space, because its base is the vertebral foramen and injury to the spine is possible. Another method of control is to apply liquid hemostatic agents.