Abstract Our understanding of the role of disease-causing variants in CFTR has culminated in two new variant-specific CFTR modulator therapies approved by the US FDA. These modulators target defects in…
Abstract Most children with cystic fibrosis (CF) in current times are likely to be picked up through newborn screening programs and confirmed by the finding of two CF-causing mutations and…
Abstract Asthma occurs as a result of the interplay of genetic susceptibility and environmental influences on the developing lungs and immune system. Asthma in children is predominantly associated with the…
Abstract Numerous drugs can cause pulmonary reactions in children. Chemotherapeutic agents are most frequently implicated, although toxic effects of other medications have been recognized. Reactions to chemotherapeutic agents may be…
Abstract Asthma is the most common cause of wheezing in school age children and adolescents. An inflammatory condition characterized by variable, reversible airway obstruction and hyperreactivity, asthma is a complex,…
Abstract Tuberculosis, caused by Mycobacterium tuberculosis, is the leading infectious cause of death worldwide; it is characterized by unique clinical stages. Adults with contagious forms of tuberculosis transmit the organism…
Abstract Epidemiology is the study of populations to discover modifiable factors that contribute to disease occurrence and natural history with a view to reducing disease burden through prevention. Asthma is…
Abstract Children with diffuse and interstitial lung disease (chILD) comprise a group of rare disorders with significant morbidity and mortality. Individually these disorders are rare but collectively they create a…
Abstract Upper airway disease, including chronic rhinitis and rhinosinusitis, affect most children with asthma. Over the past two decades, our understanding of the connection between the nose, paranasal sinuses, and…
Abstract Focus on drug development for asthma has been on development of immunomodulator therapies, with the hopes that they can eventually alter the natural course of asthma. This review focuses…
