Human Papillomavirus-Related Pulmonary Neoplasia
Fig. 19.1 (a, b) Diagrammatic representation of HPV 1 showing capsids made up of a layer of nearly continuous density. (a) Surface view, (b) cross-sectional view (Adapted from Baker TS…
RESPIRATORY
Human Metapneumovirus
Fig. 12.1 (a) hMPV infection. Note severe bronchiolitis with ulcerated bronchiolar epithelium. (b) Higher power showing accumulation of intra-alveolar macrophages. (c) Note pulmonary congestion and mild interstitial lymphocytic inflammation. (d)…
Respiratory Syncytial Virus
Fig. 11.1 Panel A: Respiratory syncytial virus pneumonia. Note cuff-like intense bronchiolar and peribronchiolar inflammatory reaction. Hematoxylin and eosin. Panel B: Same bronchiole illustrated in Panel A showing RSV antigen….
Varicella Zoster Virus
Fig. 7.1 Varicella virus. Round to hexagonal or “stop sign”-shaped, targetoid viral particles, cell culture media. Original magnification × 57000 (Courtesy of Dr. Richard Kradin and Dr. William Taylor, with…
Lung Defenses
Fig. 2.1 Antiviral action of interferon: Interferon (IFN) synthesis and release are often induced by a virus infection when cellular sensors recognize their pathogen-associated molecular patterns such as double-stranded RNA…
The Pathophysiology, Presentation and Diagnostic Investigation of Pulmonary Hypertension
Figure 1.1 Factors involved in the pathophysiology of pulmonary arterial hypertension Vasoconstriction In accordance with Poiseuille’s law the flow of blood through a vessel is proportional to its radius to…
Current Treatment Strategies, Guidelines and New Therapies
Figure 3.1 Survival plot before and after the advent of targeted vasodilator therapy, using REVEAL registry data (2012) of idiopathic and familial PAH matched to that from National Institutes of…
Molecular Biological Aspects, Therapeutic Targets and New Treatment Strategies
Figure 2.1 Histology showing remodelled pulmonary arteries in idiopathic pulmonary arterial hypertension (iPAH). Photographs of paraffin-embedded haematoxylin and eosin-stained human lung sections from patients with iPAH following lung transplantation. Medium…
The Role of Surgery in Pulmonary Hypertension
Figure 4.1 Material removed at pulmonary thromboendarterectomy, courtesy of Dr J Haney, Duke University Medical Center Reperfusion is followed by a second period of circulatory arrest to allow completion of…
