Adjuvant Chemotherapy
Five-year survival rates for patients with early-stage non–small cell lung cancer have room for improvement. Adjuvant chemotherapy results in a small but significant increase in overall survival at 5 years. Efforts…
CARDIAC SURGERY
Molecular Targets Beyond the Big 3
Lung cancer is a heterogeneous genomic disease. Smoking remains the primary cause. Genetic susceptibility and environmental exposures are responsible for 10% to 15% of cases. Targeted therapies improve survival in…
ROS1-rearranged Non–small Cell Lung Cancer
ROS1-rearranged non–small cell lung cancer (NSCLC) makes up approximately 1% to 2% of all NSCLC, is oncogenically driven by a constitutively activated ROS1 kinase paired with certain fusion partners, and…
Anaplastic Lymphoma Kinase Mutation–Positive Non–Small Cell Lung Cancer
The treatment of patients with advanced non–small cell lung cancer with anaplastic lymphoma kinase chromosomal rearrangements has been revolutionized by the development of tyrosine kinase inhibitors (TKIs). Excellent progress has…
Epidermal Growth Factor Receptor Mutations
Up to 20% of lung adenocarcinomas in the United States and Europe and 50% in Asia have activating mutations of the tyrosine kinase domain of the epidermal growth factor receptor…
Current Landscape of Personalized Therapy
Almost a half of patients diagnosed with nonesmall-cell lung cancer (NSCLC) present with incurable disease, and a significant number of patients who are treated with curative intent for early-stage disease…
Interventional Pulmonology
Interventional pulmonology is a dynamic and evolving field in respiratory medicine. Advances have improved the ability to diagnose and manage diseases of the airways. A shift toward early detection of…
Intraoperative Anesthetic and Surgical Concerns for Robotic Thoracic Surgery
Robotic thoracic surgery continues to gain momentum and is emerging as the optimal method for minimally invasive thoracic surgery. As a rapidly advancing field, continued review of the surgical and…
Management of Complications After Lung Resection
Prolonged air leak or alveolar-pleural fistula is common after lung resection and can usually be managed with continued pleural drainage until resolution. Further management options include blood patch administration, chemical…
Pain Management in Thoracic Surgery
Thoracic surgery is considered one of the most painful surgical procedures performed. Pain is mediated via several mechanisms and is affected by the surgical approach as well as patient factors….
