Location Procedure Restenosis (%) References Coronary PTA 21–55 [1–3] Coronary BMS 16–44 [1–3] Coronary DES 10 [4–11] Coronary Atherectomy 27–39 [12, 13] Renal PTA 26–100 [14] Renal BMS 17–60 [14–16]…
Fig. 48.1 Oxidative stress Physiological levels of free radicals are essential for cell differentiation, cell growth, cell apoptosis, and immunity against invading microorganisms [21–23]. However, when these free radicals overwhelm…
Fig. 51.1 Mechanisms that regulate CSPC migration (a), differentiation (b), and proliferation (c). CXCR4 C-X-C chemokine receptor type 4, SDF-1 stromal cell-derived factor-1, sVCAM soluble vascular cell adhesion molecules, SCF…
Effects of sympathetic stimulation Cellular effects Heart Increased cardiomyocyte calcium entry Increased contractility (inotropy) Myocardial hypertrophy Increased heart rate Gene expression: Increased wall stress Increased expression of fetal genes Decreased…
Hypertrophy Contractile dysfunction Calcium cycling Cytoskeletal proteins (sarcomeric, non-sarcomeric, membrane) Beta-adrenergic signaling Metabolism and bioenergetics Myocyte death (apoptosis, autophagy, stress) Endothelium and microvasculature Sympathetic innervation Circulating neurohormones, cytokines Cardiac Hypertrophy…
Edmo Atique Gabriel and Sthefano Atique Gabriel (eds.)Inflammatory Response in Cardiovascular Surgery201310.1007/978-1-4471-4429-8_47© Springer-Verlag London 2013 47. Role of BNP in Pediatric Heart Transplantation Marcelo Biscegli Jatene1 and Estela Azeka2 (1) Pediatric Cardiothoracic Surgery Unit, Heart Institute (InCor), University…
29. Palabrica T, Lobb R, Furie BC, Aronivitz M, Benjamin C, Hsu Y-M, et al. Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent platelets. Nature….
Fig. 45.1 Immature dendritic cells mature into antigen-presenting cells (APCs) within recipients’ lymph nodes and spleen. APCs present donor alloantigens on their class II MHC molecules. CD4 helper T cells…
Fig. 40.1 Mechanism of action for tranexamic acid (TXA), e-aminocaproic acid (EACA), and aprotinin during fibrinolysis (t-PA tissue-type-plasminogen activator, u-PA urokinase type-plasminogen activator, PAI plasminogen activator inhibitor, FDP fibrin degradation…
Edmo Atique Gabriel and Sthefano Atique Gabriel (eds.)Inflammatory Response in Cardiovascular Surgery201310.1007/978-1-4471-4429-8_37© Springer-Verlag London 2013 37. Dysfunctional Mechanisms of Anti-inflammation in Aortic Stenosis David A. Fullerton1 and Xianzhong Meng1 (1) Division of Cardiothoracic Surgery, The University of Colorado…
