Microenvironment and Lung Cancer
Summary of Key Points • There is untapped potential for targeted lung cancer prevention and therapy that requires, as a first step, a more clear delineation of the biology underlying…
Stem Cells and Lung Cancer: In Vitro and In Vivo Studies
Abstract There have been recent advances in isolation and characterization of the putative cells of origin associated with non-small cell lung cancer and small cell lung cancer. Key biochemical pathways…
Preclinical Biomarkers for the Early Detection of Lung Cancer
Abstract Noninvasive biomarkers in the blood, sputum, airway epithelium, or exhaled breath can be combined with imaging to detect early-stage lung cancer and improve mortality. Lung cancer biomarkers may reduce…
Chemoprevention of Lung Cancer and Management of Early Lung Cancer
Keywords chemoprevention, CT screening, early detection, lung cancer, smoking cessation Summary of Key Points • Most chemoprevention research is focused on natural products and is not amenable to traditional…
Screening for Lung Cancer
Keywords early detection, lung neoplasms, screening Summary of Key Points • The National Lung Screening Trial has definitively shown a reduction in lung cancer mortality in a research setting…
Genetic Susceptibility to Lung Cancer
Abstract Evidence for the role of genetic susceptibility to lung cancer is substantial even while 85% to 90% of lung cancer is attributable to cigarette smoking. Studies demonstrate familial aggregation…
Tobacco Control and Primary Prevention
Abstract Tobacco is the single greatest contributor to development of lung cancer. Nearly all societies across the globe are afflicted with the tobacco epidemic, and smoking rates are rising for…
Lung Cancer in Never-Smokers: A Different Disease
Abstract Major clinical, ethnic, gender, and histology differences between lung cancers arising from smokers and never-smokers, coupled with their different etiologic factors and major molecular differences, indicate that they represent…
Assessing and Treating Tobacco Use in Lung Cancer Care
Summary of Key Points • Addressing tobacco dependence in patients with cancer increases the quality of care by reducing their risk for treatment complications, improving their prognosis, and reducing the…
Classic Epidemiology of Lung Cancer
Abstract Lung cancer remains the highest contributor to cancer mortality worldwide. Among woman, lung cancer incidence and mortality is still increasing in many countries. The epidemiology of lung cancer is…
