Gender-Related Differences in Lung Cancer
Abstract Lung cancer is no more a “male disease” and an exponential increase in the incidence of the disease among females has been registered during the last 40 years. In…
Clinical Presentation and Prognostic Factors in Lung Cancer
Summary of Key Points • Most people with lung cancer are symptomatic at the time of initial presentation; however, between 5% and 15% of people may be asymptomatic. • Alarming…
Humoral and Cellular Immune Dysregulation and Lung Cancer
Summary of Key Points • Humoral and cellular immune dysregulation in the tumor microenvironment contributes to immune evasion, a key hallmark of lung cancer. • Immunosuppressive mechanisms observed in lung…
MicroRNAs as Biomarkers for Lung Cancer
Summary of Key Points • The biologic roles of microRNAs (miRNAs) in lung cancer indicate their correlation with disease status, prognosis, and therapeutic outcome. The discovery of miRNAs has opened…
Microenvironment and Lung Cancer
Summary of Key Points • There is untapped potential for targeted lung cancer prevention and therapy that requires, as a first step, a more clear delineation of the biology underlying…
Stem Cells and Lung Cancer: In Vitro and In Vivo Studies
Abstract There have been recent advances in isolation and characterization of the putative cells of origin associated with non-small cell lung cancer and small cell lung cancer. Key biochemical pathways…
Preclinical Biomarkers for the Early Detection of Lung Cancer
Abstract Noninvasive biomarkers in the blood, sputum, airway epithelium, or exhaled breath can be combined with imaging to detect early-stage lung cancer and improve mortality. Lung cancer biomarkers may reduce…
Chemoprevention of Lung Cancer and Management of Early Lung Cancer
Keywords chemoprevention, CT screening, early detection, lung cancer, smoking cessation Summary of Key Points • Most chemoprevention research is focused on natural products and is not amenable to traditional…
Screening for Lung Cancer
Keywords early detection, lung neoplasms, screening Summary of Key Points • The National Lung Screening Trial has definitively shown a reduction in lung cancer mortality in a research setting…
Genetic Susceptibility to Lung Cancer
Abstract Evidence for the role of genetic susceptibility to lung cancer is substantial even while 85% to 90% of lung cancer is attributable to cigarette smoking. Studies demonstrate familial aggregation…
