Introduction Evidence-based treatments for patients with myocardial infarction (MI) have improved outcomes, with substantive reductions in mortality rates ( Chapter 2 ). Nevertheless, patients who survive an acute MI remain…
Introduction Mortality for patients with myocardial infarction (MI) remains unacceptably high despite improvements in medical therapy and revascularization. Death, when it occurs, is often caused by cardiac dysfunction, which leads…
Introduction Myocardial infarction (MI) is defined by myocyte necrosis. If large in its territory or critical in its location, this injury can lead to loss of contractile function or other…
Introduction Noninvasive testing after presentation with acute myocardial infarction (MI) plays an essential role in patient management. Noninvasive testing complements clinical assessment of risk stratification and can be used to…
Introduction There has been a major decline in the incidence of myocardial infarction (MI) in the developed world, with the proportion of ST-elevation MI (STEMI) decreasing and the proportion of…
Introduction The combination of aspirin with P2Y 12 inhibitors, which is also known as dual antiplatelet therapy, is the standard of care for oral antiplatelet treatment in patients presenting with…
Introduction Clinical outcomes after acute coronary syndrome (ACS) have significantly improved over time. A significant proportion of the reduction in mortality has been the result of development and adoption of…
Introduction The term “reperfusion injury” refers to cellular damage that occurs during the reperfusion phase after an episode of ischemia. If reperfusion occurs after a short period of ischemia, all…
Introduction Despite improvements in secondary preventive care and risk factor modification, there is a persistently elevated risk of recurrent cardiovascular (CV) events after experiencing a myocardial infarction (MI), with more…
Acknowledgments This work was supported in part by NIH grants P01 HL-78825 and UM1 HL-113530 (CCTRN). Introduction Cell-based therapy is an exciting new treatment modality that has the potential to…
