A Bayesian re-analysis of the STRESS trial

Jun 27, 2026 by in CARDIOLOGY Comments Off on A Bayesian re-analysis of the STRESS trial
Highlights • This study presents a Bayesian re-analysis of the STRESS trial, which evaluated prophylactic methylprednisolone versus placebo in 1,200 infants undergoing heart surgery with cardiopulmonary bypass. • The Bayesian…
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PRospective evaluation of the European Society of Cardiology 0/1h-algorithm`s safety and efficacy for triage of patients with suspected myocardial infarction (PRESC1SE-MI): Rationale and design of a prospective international multicenter stepped-wedge cluster randomized controlled trial

Jun 27, 2026 by in CARDIOLOGY Comments Off on PRospective evaluation of the European Society of Cardiology 0/1h-algorithm`s safety and efficacy for triage of patients with suspected myocardial infarction (PRESC1SE-MI): Rationale and design of a prospective international multicenter stepped-wedge cluster randomized controlled trial
Highlights • There is a lack of evidence from a large prospective, international randomized controlled trial evaluating whether implementing the more rapid ESC-0/1h-algorithm at late-adopting centers across diverse countries and…
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Evolocumab before percutaneous coronary intervention for acute myocardial infarction: Design of the AMUNDSEN trial

Jun 27, 2026 by in CARDIOLOGY Comments Off on Evolocumab before percutaneous coronary intervention for acute myocardial infarction: Design of the AMUNDSEN trial
ABSTRACT Rationale PCSK9 inhibitors are currently recommended as third-line therapy for post–myocardial infarction (MI) patients, added to high-dose statin, ezetimibe, and potentially bempedoic acid when the LDL-C target of <55…
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Rationale and design of REAC-TAVI 2: Single antiplatelet treatment with ticagrelor vs aspirin after transcatheter aortic valve implantation

Jun 27, 2026 by in CARDIOLOGY Comments Off on Rationale and design of REAC-TAVI 2: Single antiplatelet treatment with ticagrelor vs aspirin after transcatheter aortic valve implantation
Highlights • REAC-TAVI 2 will study the effects of aspirin vs. low-dose ticagrelor post-TAVI. • The study will randomize patients with high ischemic risk post-TAVI to aspirin vs. ticagrelor. •…
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Anatomical, physiological and inflammatory characterization of nonculprit vessels in patients undergoing primary PCI for ST-elevation myocardial infarction in the presence of multivessel disease: Rationale and design of the PICNIC study

Jun 27, 2026 by in CARDIOLOGY Comments Off on Anatomical, physiological and inflammatory characterization of nonculprit vessels in patients undergoing primary PCI for ST-elevation myocardial infarction in the presence of multivessel disease: Rationale and design of the PICNIC study
ABSTRACT Background Up to 50% of patients presenting with ST-elevation myocardial infarction (STEMI) have multivessel coronary artery disease (CAD). Randomized trials suggest that complete revascularization improves outcomes, but the mechanism…
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REview and improvement of cardiac implanTable device Infection management qualitY initiative (RECTIFY): Rationale and design for a cardiac implantable electronic device infection quality initiative demonstration project

Jun 27, 2026 by in CARDIOLOGY Comments Off on REview and improvement of cardiac implanTable device Infection management qualitY initiative (RECTIFY): Rationale and design for a cardiac implantable electronic device infection quality initiative demonstration project
ABSTRACT Background Cardiac implantable electronic device (CIED) infections are a growing concern due to their associated high morbidity, mortality, and healthcare costs. Current guidelines given complete device and lead removal…
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Distal versus conventional radial large-bore access for percutaneous coronary intervention of complex coronary lesions: Rationale and design of the DISCO COMPLEX randomized superiority trial

Jun 27, 2026 by in CARDIOLOGY Comments Off on Distal versus conventional radial large-bore access for percutaneous coronary intervention of complex coronary lesions: Rationale and design of the DISCO COMPLEX randomized superiority trial
Highlights • DRA is a valid alternative to conventional TRA for coronary angiography and PCI. • Randomized evidence on large-bore DRA for patients undergoing complex PCI is scarce. • DISCO…
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A just-in-time adaptive mobile application intervention to reduce sodium intake and blood pressure in patients with hypertension: Rationale and design of the LowSalt4Life 2 trial

Jun 27, 2026 by in CARDIOLOGY Comments Off on A just-in-time adaptive mobile application intervention to reduce sodium intake and blood pressure in patients with hypertension: Rationale and design of the LowSalt4Life 2 trial
ABSTRACT Background Excess dietary sodium intake is a major contributor to hypertension (HTN) and cardiovascular disease in the U.S., yet most Americans exceed recommended sodium intake levels. Despite the established…
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Mavacamten in symptomatic adolescent patients with obstructive hypertrophic cardiomyopathy: design of the phase 3 SCOUT-HCM trial

Jun 27, 2026 by in CARDIOLOGY Comments Off on Mavacamten in symptomatic adolescent patients with obstructive hypertrophic cardiomyopathy: design of the phase 3 SCOUT-HCM trial
Highlights • Pediatric HCM is a rare disease associated with substantial morbidity and mortality. • Current therapies for pediatric HCM do not target the underlying pathophysiology. • Mavacamten is a…
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Risk-guided disease management to prevent heart failure in adult cancer survivors of previous cardiotoxic cancer treatments: Baseline results of the REDEEM trial

Jun 27, 2026 by in CARDIOLOGY Comments Off on Risk-guided disease management to prevent heart failure in adult cancer survivors of previous cardiotoxic cancer treatments: Baseline results of the REDEEM trial
ABSTRACT Background Adult cancer survivors are at increased risk of heart failure (HF) due to standard risk factors and cancer treatment-related cardiac dysfunction. However, the prevalence and treatment of subclinical/stage…
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