Signal Transduction: Proliferative Signaling The signaling systems that regulate cell size, shape, and composition play an important role in the pathophysiology of cardiac disease. These systems, along with those that…
Signal Transduction: Functional Signaling The vie constante, where life manifests itself independently of the external environment [is] characterized by freedom and independence … Here life is never suspended, but flows…
Excitation-Contraction Coupling: Extracellular and Intracellular Calcium Cycles It is quite … impossible to explain the rapid development of full activity in a [skeletal muscle] twitch by assuming that it is…
Active State, Length-Tension Relationship, and Cardiac Mechanics T ension development and shortening by the heart depend on interactions between the contractile proteins (Chapter 4) and their interplay with the cytoskeleton…
The Contractile Proteins Cardiac contraction and relaxation depend on interactions among the six proteins listed in Table 4-1. This chapter describes each of these proteins, how they interact as actomyosins…
The Cytoskeleton Come to me now, you muses who live on Olympus for you are goddesses, are everywhere and know all things, while we only hear of glory but do…
Energy Utilization (Work and Heat) Muscle research in the early 19th century centered on the then new field of thermodynamics, notably the first law, which states that the sum of…
Energetics and Energy Production L arge amounts of chemical energy are expended when the heart pumps blood under pressure into the aorta and pulmonary artery. Most of this energy is…
Structure of the Heart and Cardiac Muscle It has been shown by reason and experiment that blood by the beat of the ventricles flows through the lungs and heart and…
