Neuroblastoma, Ganglioneuroblastoma, and Ganglioneuroma of the Mediastinum Borislav A. Alexiev, M.D. Jennifer M. Boland, M.D. Allen P. Burke, M.D. Introduction Neural tumors constitute 15% of mediastinal tumors in adults, and…
Mediastinal Nerve Sheath Tumors (Schwannoma, Neurofibroma, Malignant Peripheral Nerve Sheath Tumor) Borislav A. Alexiev, M.D. Jennifer M. Boland, M.D. General Peripheral nerve sheath tumors encompass a spectrum of well-defined clinicopathologic…
Mediastinal Gray Zone Lymphoma (B-Cell Lymphoma, Unclassifiable, with Features Intermediate Between Diffuse Large B-Cell Lymphoma and Classical Hodgkin Lymphoma) Borislav A. Alexiev, M.D. Rima Koka, M.D., Ph.D. Terminology Mediastinal gray…
Anaplastic Large Cell Lymphoma (ALK-Positive and ALK-Negative) Borislav A. Alexiev, M.D. Rima Koka, M.D., Ph.D. Background ALK-positive anaplastic large cell lymphoma (ALCL) is a T-cell lymphoma that is characterized by…
Histiocytic and Dendritic Cell Neoplasms (Histiocytic Sarcoma, Tumors Derived from Langerhans Cells, Interdigitating Dendritic Cell Sarcoma, Follicular Dendritic Cell Sarcoma) Borislav A. Alexiev, M.D. Rima Koka, M.D., Ph.D. Follicular Dendritic…
Hodgkin Lymphoma Borislav A. Alexiev, M.D. Rima Koka, M.D., Ph.D. Terminology Hodgkin lymphoma (HL) is a monoclonal lymphoid neoplasm (in most instances derived from B cells) composed of mononuclear Hodgkin…
Precursor T-Cell Lymphoblastic Lymphoma/Leukemia Borislav A. Alexiev, M.D. Rima Koka, M.D., Ph.D. Terminology Precursor T-lymphoblastic lymphoma/leukemia is a neoplasm of lymphoblasts committed to the T-cell lineage, typically composed of small…
Thymic Extranodal Marginal Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue Borislav A. Alexiev, M.D. Rima Koka, M.D., Ph.D. Terminology Primary thymic extranodal marginal zone B-cell lymphoma (MZBL) of mucosa-associated lymphoid…
Primary Mediastinal Large B-Cell Lymphoma Borislav A. Alexiev, M.D. Rima Koka, M.D., Ph.D. Terminology Primary lymphomas of the mediastinum are believed to arise from mediastinal lymph nodes or, when in…
Mediastinal Germ Cell Tumor with Somatic-Type and Hematologic Malignancy Borislav A. Alexiev, M.D. Allen P. Burke, M.D. Terminology Germ cell tumor with somatic-type malignancy (GCT-STM) denotes a GCT containing a…
