Giant Cell Myocarditis
Giant Cell Myocarditis Allen P. Burke, M.D. Pathogenesis Historically termed “Fiedler myocarditis,”1 giant cell myocarditis is a rare disorder with unclear cause. An autoimmune cause is likely, because patients often…
Hypersensitivity, Eosinophilic, and Toxic Myocarditis
Hypersensitivity, Eosinophilic, and Toxic Myocarditis Allen P. Burke, M.D. Definitions “Hypersensitivity myocarditis” is an etiologic definition that denotes a reaction to an ingested substance, usually a drug, that usually, but…
Lymphocytic Myocarditis
Lymphocytic Myocarditis Fabio R. Tavora, M.D., Ph.D. Allen P. Burke, M.D. Pathogenesis “Lymphocytic myocarditis” describes the histologic pattern of the most common form of myocarditis, which is associated with viruses…
Restrictive Cardiomyopathy, Endocardial Fibrosis, and Eosinophilic Endomyocarditis
Restrictive Cardiomyopathy, Endocardial Fibrosis, and Eosinophilic Endomyocarditis Fabio R. Tavora, M.D., Ph.D. Allen P. Burke, M.D. Restrictive Heart Disease Restrictive heart disease refers to hemodynamic cardiac alterations that result from…
Stress Cardiomyopathy
Stress Cardiomyopathy Allen P. Burke, M.D. Joseph J. Maleszewski, M.D. Terminology Stress cardiomyopathy refers to catecholamine-induced myocardial injury that results in transient left ventricular systolic dysfunction. There are two recognized…
Left Ventricular Noncompaction
Left Ventricular Noncompaction Allen P. Burke, M.D. Definition Left ventricular noncompaction is defined by prominent ventricular trabeculations, deep trabecular recesses, and a thin compacted layer, mostly involving the left ventricle,…
Miscellaneous Genetic Cardiomyopathies
Miscellaneous Genetic Cardiomyopathies Allen P. Burke, M.D. Joseph J. Maleszewksi, M.D. Infantile and Genetic Cardiomyopathy A genetic basis underlies a majority of nonischemic cardiomyopathies (Chapters ). In most cases of…
Arrhythmogenic Cardiomyopathy
Arrhythmogenic Cardiomyopathy Allen P. Burke, M.D. Fabio R. Tavora, M.D., Ph.D. Background The concept of arrhythmogenic cardiomyopathy (AC) has evolved over the last 25 years, resulting in a variety of…
Hypertrophic Cardiomyopathy
Hypertrophic Cardiomyopathy Allen P. Burke, M.D. Fabio R. Tavora, M.D., Ph.D. Joseph J. Maleszewski, M.D. General Considerations Hypertrophic cardiomyopathy (HCM) is a heart muscle disease that results in cardiac hypertrophy…
Dilated Cardiomyopathy
Dilated Cardiomyopathy Allen P. Burke, M.D. Joseph J. Maleszewski, M.D. Classification Primary Versus Secondary Dilated Cardiomyopathy Dilated cardiomyopathy (DCM) is heart disease usually characterized by four-chamber dilatation in the absence…
