Chronic Rheumatic and Autoimmune Valve Disease Allen P. Burke, M.D. Introduction Postrheumatic or postinflammatory valve disease refers to scarring of the valve that occurs secondary to an autoimmune reaction following…
Carcinoid Heart Disease Allen P. Burke, M.D. Fabio R. Tavora, M.D., Ph.D. Pathogenesis Carcinoid heart disease occurs when active secretory products of lowgrade neuroendocrine tumors damage the endocardium of the…
Aortic Insufficiency Allen P. Burke, M.D. Fabio R. Tavora, M.D., Ph.D. Etiology In the previous century, aortic insufficiency was most commonly secondary to postinflammatory (rheumatic) valve disease. Postinflammatory fibrosis causes…
Degenerative Valve Disease-Calcific Aortic Stenosis and Mitral Annular Calcification Allen P. Burke, M.D. Joseph J. Maleszewski, M.D. Introduction Degenerative aortic valve disease extensively involves the cusps themselves and results in…
Cardiac Allograft Vasculopathy Joseph J. Maleszewski, M.D. Allen P. Burke, M.D. Overview Cardiac allograft vasculopathy (CAV, or, loosely, chronic rejection) is a primarily intimal disease that is unique to allograft…
Evaluation of Excised Cardiac Valves Allen P. Burke, M.D. General Considerations A gross photograph generally provides significantly more information than do histologic sections or long gross descriptions. However, histologic evaluation…
Antibody-Mediated Cardiac Allograft Rejection Allen P. Burke, M.D. Introduction Antibody-mediated rejection is an immunologic response to the cardiac allograft distinct from cellular rejection by its biology and histologic findings. It…
Acute Cellular Rejection Allen P. Burke, M.D. Fabio R. Tavora, M.D., Ph.D. Introduction Endomyocardial biopsy surveillance, with frequent biopsies in the early months and standardized treatments for particular clinical situations,…
Pericarditis Fabio R. Tavora, M.D., Ph.D. Allen P. Burke, M.D. Incidence and Clinical Findings Pericardial inflammation can be the result of infections, autoimmune disease, renal failure, radiation, malignancy, or trauma…
Infections of the Myocardium Fabio R. Tavora, M.D., Ph.D. Allen P. Burke, M.D. Viral and Postviral Myocarditis Coxsackievirus type B is a type of enterovirus that causes a flu-like systemic…
