Fig. 7.1 Schematic representation of a sarcomere with a scheme showing its main molecular constituents below. Myosin is represented in blue, titin in red and the M-band in purple. Dashed…
Fig. 4.1 Cardiac Sarcomere. The sarcomere is the basic contractile unit of muscle. The lateral boundaries of a sarcomere are defined by protein-dense Z-discs. The I-band is the region surrounding…
Fig. 10.1 AMPK structure. (a) AMPK domain structure of the three AMPK subunits (SID, subunit interaction domains; AID, autoinhibitory domain; CBM, carbohydrate-binding module; CBS, cystathionine-β synthase). (b) AMPK complex topology….
Fig. 2.1 The multi-scale structure of the heart. The function of the heart is dependent on its hierarchical architecture, which spans organ, tissue, cellular, and molecular levels 2.1 Structure–Function Relationships…
Fig. 1.1 Cardiac cytoarchitecture changes during development and in disease. Schematic representations of an embryonic cardiomyocyte (a) showing its polygonal shape, an adult cardiomyocyte (b), which is rod-shaped and a…
Fig. 11.1 Schematic drawing of a cardiomyocyte with the localisation of the eight most common sarcomeric HCM disease genes in the thick and thin filament. Additionally, the localisation non-contractile proteins…
Fig. 8.1 Schematic structure of a sarcomere. Illustrated proteins are described throughout this chapter. Gray: Z-disc-associated proteins; lilac: proteins involved in mechanotransduction; brown: proteins involved in protein turnover and degradation;…
Fig. 5.1 An isolated cardiac myocyte in which sarcomeres are delineated by an antibody staining against α-actinin Several landmarks are readily observable to delineate the sarcomere. The Z line is…
Fig. 6.1 Signal transduction pathways and kinases involved in phosphorylation of cardiac titin N2-Bus and PEVK. AC adenylate cyclase, ßAR beta-adrenergic receptor, AngII angiotensin II, ANP atrial natriuretic peptide, ATP…
(1) The Lindner Center for Research and Education The Christ Hospital, The Christ Hospital Physicians Ohio Heart and Vascular Center, Cincinnati, OH, USA KeywordsCCTA in the emergency roomCT-STAT studyROMICAT…
