Heart Failure Controversies
(1) University of Ottawa The Ottawa Hospital, Ottawa, ON, Canada Are ARBs as Effective as ACE Inhibitor Therapy for Heart Failure? The carefully run RCTs CHARM (2003), Val-HeFT (2001),…
Hypertension Controversies
(1) University of Ottawa The Ottawa Hospital, Ottawa, ON, Canada Beta-Blockers Should Not Remain First Choice in the Treatment of Primary Hypertension: True or False? A meta-analysis by Lindholm…
Beta-Blocker Controversies
(1) University of Ottawa The Ottawa Hospital, Ottawa, ON, Canada Beta-Blockers Are not a Good Initial Choice for Hypertension: True or False? A meta-analysis (Lindholm et al. 2005) concluded…
Calcium Antagonists (Calcium Channel Blockers)
(1) University of Ottawa The Ottawa Hospital, Ottawa, ON, Canada There are important, subtle differences among the available calcium antagonists that may affect the choice in treating individual patients….
ACE Inhibitor ARB Controversies
(1) University of Ottawa The Ottawa Hospital, Ottawa, ON, Canada ACE Inhibitors Versus ARBs: Does the Choice Matter? Angiotensin-converting enzyme (ACE) inhibitors have been shown in large randomized controlled…
Calcium Antagonist Controversies
(1) University of Ottawa The Ottawa Hospital, Ottawa, ON, Canada Calcium Antagonists Cause an Increased Incidence of HF and MI: True or False? Calcium antagonists without doubt cause an…
Cardiac Cytoarchitecture: How to Maintain a Working Heart—Waste Disposal and Recycling in Cardiomyocytes
Fig. 12.1 The ubiquitin-proteasome system and steps in the ubiquitylation and degradation of cellular substrate proteins. The ubiquitin and 26S proteasome structures were adopted from Vijay-Kumar et al. (1987) and…
The Intercalated Disc: A Focal Point for Sarcomere Growth and Disease
Fig. 3.1 (a) Changes of length and width of mouse cardiomyocytes during growth. Birth day set as 0. Data from embryonic day 8.5 (−11.5) to 4 days after birth taken…
The Nuclear Envelope in Cardiac Health and Disease
Fig. 9.1 The nuclear envelope and the nuclear lamina. The nuclear envelope provides a physical barrier for nuclear compartmentalisation and a platform for communication between the nucleus and cytoskeletal domains…
