Heart Failure
(1) University of Ottawa The Ottawa Hospital, Ottawa, ON, Canada The Size of the Problem The world faces an epidemic of heart failure (HF). The plague of HF is…
Newer Agents
(1) University of Ottawa The Ottawa Hospital, Ottawa, ON, Canada Apixaban Patients with AF have a fivefold increased risk of stroke, particularly in patients with valvular heart disease and…
Hypertension
(1) University of Ottawa The Ottawa Hospital, Ottawa, ON, Canada Relevant Key Issues There are more than one billion individuals with hypertension worldwide; the number is predicted to grow…
Cardiac Arrest
(1) University of Ottawa The Ottawa Hospital, Ottawa, ON, Canada Sudden cardiac death accounts for >50 % of all coronary artery disease deaths and 15–20 % of all deaths…
Drug Interactions
(1) University of Ottawa The Ottawa Hospital, Ottawa, ON, Canada Several cardiac drugs manifest some form of interaction with each other or with noncardiac drugs. It is of paramount…
Cardiac Drugs During Pregnancy and Lactation
(1) University of Ottawa The Ottawa Hospital, Ottawa, ON, Canada Most cardiovascular agents (like all other drugs) must be avoided in the first trimester of pregnancy because they may…
Antiplatelet Agents, Anticoagulants, Factor Xa Inhibitors, and Thrombin Inhibitors
(1) University of Ottawa The Ottawa Hospital, Ottawa, ON, Canada Antiplatelet Agents Antiplatelet agents are used in virtually all patients with coronary heart disease (CHD). Aspirin, the pioneer hallmark…
Dyslipidemias
(1) University of Ottawa The Ottawa Hospital, Ottawa, ON, Canada Diagnosis Persons with a marked increase in serum levels of cholesterol to >350 mg/dL (9 mmol/L) represent a very…
Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers
(1) University of Ottawa The Ottawa Hospital, Ottawa, ON, Canada Angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs) play a pivotal role in the management of heart…
