Sarcoidosis-Associated Pulmonary Hypertension
Fig. 13.1 Hematoxylin and eosin stained lung biopsy from a patient with sarcoidosis and severe pulmonary hypertension. (a) A granuloma (black arrow) in the wall of a pulmonary vein (b)…
Management of Sudden Death Risk Related to Cardiac Sarcoidosis
Class I Recommendation ICD implantation is recommended in patients with CS and one or more of the following: 1. Spontaneous sustained ventricular arrhythmias, including prior cardiac arrest. 2. The LVEF…
Immunosuppressive Management of Cardiac Sarcoidosis
Topic Procedure N (% endorsing) Indications for initiation of immunomodulatory therapy (a) Hypermetabolic activity on a cardiac FDG–PET scan 24 (77.4 %) (b) Delayed enhancement on cardiac MRI 19 (61.3 %) (c)…
Patient-Centered Care for Sarcoidosis
© Springer International Publishing Switzerland 2015Andrew M. Freeman and Howard D. Weinberger (eds.)Cardiac Sarcoidosis10.1007/978-3-319-14624-9_15 15. Patient-Centered Care for Sarcoidosis Darlene Kim1 and Howard D. Weinberger1 (1) Division of Cardiology, Department of Medicine, National Jewish Health, 1400 Jackson St.,…
Invasive Procedures and Endomyocardial Biopsy
Major complications Total <1.0 % Death None Tamponade with pericardiocentesis 0.08–0.80 % Hemothorax or pneumothorax None Permanent complete AV block with permanent pacemaker needed <0.04 % Urgent cardiac surgery…
Acute Management of Cardiac Sarcoidosis
JMHW HRS 2014 Definite diagnosis Histologic evidence of cardiac non-caseating granuloma Histologic evidence of cardiac non- caseating granuloma, with no alternative cause identified (i.e., infection) Probable/clinical diagnosis Histological diagnosis…
Clinical Presentations
Fig. 3.1 Complete heart block Cardiac sarcoidosis may be mis-diagnosed as arrhythmogenic right ventricular cardiomyopathy (ARVC) [1, 5–7]. Cardiac sarcoidosis should be considered in patients with non-ischemic cardiomyopathy, left ventricular…
Standard Screening for Cardiac Sarcoidosis
Histologic diagnosis Endomyocardial biopsy demonstrating noncaseating epithelioid granulomas Clinical diagnosis Suspect cardiac sarcoidosis with (a) + one other (a) Complete right bundle branch block, AV block, ventricular tachycardia, ventricular premature…
High Yield Epidemiology
Fig. 1.1 A myocardial biopsy obtained via right heart catheterization showing giant cells consistent with sarcoidosis As sarcoidosis is now more widely recognized and with increased rigor in its diagnosis,…
Pathophysiology: From Genetics to Viruses and More
Genetics: chromosomal abnormalities, angiotensin-converting enzyme genes T cell abnormalities T cell receptor abnormalities Vitamin D receptor gene abnormalities Viruses: HHV Mycobacterial diseases and acid-fast cell wall-deficient organisms Beryllium exposure Humidity/water…
