Wall constituent Changes Myocytes Hypertrophy, lengthening Reexpression of fetal gene program Altered excitation–contraction coupling Impaired energy metabolism Defective myofibrillar content and function Apoptosis, necrosis Vasculature Endothelial dysfunction Intimal thickening Smooth…
300 ms) can benefit from pacing. Pacemakers also are used to treat advanced heart failure with major intraventricular conduction disorders, mainly left bundle-branch block (biventricular pacing for resynchronization). Automatic calibration leads…
). The plane of the valve is not flat, but resembles a saddle. During the cardiac cycle, the mitral valve size and shape change. In particular, the size of the…
Component Constituents Myofilaments Actin, tropomyosin, troponin-C/I/T Myosin Hemisarcomere Titin, nebulin, MyBPc3 Z disc α-actinin, Tcap (telethonin), CRSP3 (MLP) M line, H zone Myomesin CRSP3 (MLP) cardiac cysteine and glycine-rich protein-3 (or muscle LIM…
Stent Drug (concentration) Polymer Polymer thickness (μm) Release kinetics (days) Metal Geometry Strut thickness (μm) First generation stents CYPHER Sirolimus (140 μg/cm2) Polyethelyne co-vinyl acetate & PBMA 12.6 80…
(1) Laboratory of Genetics and Molecular Cardiology, Heart Institute, São Paulo, SP, Brazil (2) Federal University of São Paulo Medical School, São Paulo, SP, Brazil (3) Department of Cardiac Catheterization…
RCT N° patients Active treatment Comparator Time of active treatment Time to FU angiography (if mandatory) Max period FU Primary endpoint IMPRESS [15] 83 Prednisone Placebo 45 days 6 months…
Fig. 20.1 (a) BMS healing in animals vs. humans. Line plot showing the temporal relation of peak neointimal growth in animals and humans following the placement of bare stainless steel…
(1) Department of Interventional Cardiology, Otamendi Hospital, Buenos Aires, Argentina (2) Cardiac Unit, Department of Interventional Cardiology, Revista Argentina de Cardioagiologia Intervencionista (RACI), Otamendi Hospital, Buenos Aires, Argentina (3) Interventional…
Fig. 17.1 Intravascular imaging (IVUS) in left main stem coronary intervention. Mid-shaft LMS stenosis with IVUS imaging (arrows) to assess composition of plaque and to aid in vessel sizing (a,…
