Phenotype Gene SNP OR 95 % CI P value Reference Bevacizumab-induced hypertension EGF rs4444903 1.57 1.17–2.11 0.0025 [37] EGF rs9992755 1.45 1.08–1.96 0.014 [37] WNK1 rs11064560 1.41 1.04–1.92 0.028 [37]…
Blood pressure, mmHg NICE 2011 [3] ESH/ESC 2013 [4] AHA/ACC/CDC 2013 [6] ASH/ISH 2013 [5] JSH 2014 [7] JNC 8 [2] Definition of hypertension ≥140/90 and daytime ABPM (or home…
Medication Dosing Special considerations Aspirin Initial dose: 324 mg non-enteric coated chewed at presentation Maintenance dose: 81 mg daily Clopidogrel Initial: 300–600 mg loading dose Maintenance: 75 mg daily Prasugrel…
Definition Criteria for acute myocardial infarction Types Reinfarction Myocardial infarction redefined—a consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction…
Acute coronary syndrome Plaque erosion occurs more frequently in younger women than in men. Unlike in plaque rupture, the plaque in erosion has a thickened fibrous cap and minimal calcification.Women…
Drug class Main mechanism of action Preload Afterload ACEi Reduced conversion of angiotensin I to angiotensin II ↓↓ ↓↓ ARB Inhibition of angiotensin II AT-1 receptors ↓↓ ↓↓ Beta-blockers Inhibition…
Fig. 4.1 Excitation–contraction coupling: Ca2+ cycling is regulated by transporters and channels on the plasma membrane and sarcoplasmic reticulum. Under pathological conditions, such as hypertrophy and heart failure, defects in…
Coronary artery disease other than atherosclerosis Arteritis Luetic Granulomatous (Takayasu disease) Polyarteritis nodosa Mucocutaneous lymph node (Kawasaki) syndrome Disseminated lupus erythematosus Rheumatoid spondylitis Ankylosing spondylitis Trauma to coronary arteries Laceration…
1 Secondary prevention Clinical history of ASCVD 2 Primary prevention LDL-C ≥190 mg/dL, age ≥21 years 3 Primary prevention Diabetes: age 40–75 years, LDL-C 70–189 mg/dL 4 Primary prevention No…
Fig. 10.1 The schematic illustrates the main structural components of a striated muscle cell sarcomere. Thin filaments (I bands) are composed of actin monomers and tropomyosin. The thick filaments (A…
