Fig. 13.1 MicroRNAs involved in the pathogenesis of cardiovascular disease. The figure illustrates the contribution of selected miRNAs to remodeling of the heart. Manipulation of these miRNAs may hinder the…
Fig. 6.1 Innervation of the heart by the autonomic nervous system – from central to peripheral inputs. The sympathetic and parasympathetic (vagus) nerves are marked. Vagus afferents (sensory nerves) are…
Fig. 5.1 Signaling pathways of α- and β-adrenergic receptors. Note that α2AR is not expressed in cardiomyocytes. β2AR can be coupled with both Gαs and Gαi. Other receptors are coupled…
(1) The Molecular Cardiology and Neuromuscular Institute, Highland Park, NJ, USA Abstract Mitochondria are not generated de novo but grow and divide adding newly synthesized constituents to preexisting mitochondrial…
(1) The Molecular Cardiology and Neuromuscular Institute, Highland Park, NJ, USA Abstract Both clinical studies and animal models have shown that mitochondria are at the center of the pathophysiology…
(1) The Molecular Cardiology and Neuromuscular Institute, Highland Park, NJ, USA Abstract The majority of the cellular energy is produced in the form of ATP by the oxidative phosphorylation…
(1) The Molecular Cardiology and Neuromuscular Institute, Highland Park, NJ, USA Abstract Besides their central bioenergetic role in supplying ATP, heart mitochondria play an essential role in the regulatory…
(1) The Molecular Cardiology and Neuromuscular Institute, Highland Park, NJ, USA Abstract Abnormalities in cardiac mitochondrial respiratory enzymes and mitochondrial DNA have been found in an increasing number of…
(1) The Molecular Cardiology and Neuromuscular Institute, Highland Park, NJ, USA Abstract Mitochondria are dynamic organelles displaying considerable structural complexity and diversity in terms of the folding of their…
(1) The Molecular Cardiology and Neuromuscular Institute, Highland Park, NJ, USA Abstract Mitochondrial disorders encompass a highly heterogeneous group of diseases characterized by not only defects in the OXPHOS…
