Fig. 12.1 Proteolytic processing of B-type natriuretic peptides (Reproduced from Motiwala and Januzzi [82], with permission from the Nature Publishing Group) In peripheral organs, biologically active NPs bind to natriuretic…
Fig. 59.1 The conotruncal anomalies can be seen as a related group of disorders characterized by an altered rotational relationship between the aorta and the pulmonary artery. (a) Normal heart,…
Severity of aortic stenosis Physical sign Mild (n = 74) Moderate (n = 49) Severe (n = 19) ASEM 95 % 100 % 100 % Prolonged duration ASEM 3 % 63 % 84 % Late-peaking…
Fig. 15.1 Gene therapy clinical trial data. (a) Relative distribution of clinical trials by disease. (b) Relative distribution of cardiovascular gene therapy clinical trials by vector used 15.2 Gene Therapy…
Fig. 34.1 Possible mechanisms involving angiotensin II (Ang II), endothelin (ET), oxidative stress, and nitric oxide in enhanced expression of Giα protein in hypertension. Giα protein expression is enhanced in…
Phenotype Gene SNP OR 95 % CI P value Reference Bevacizumab-induced hypertension EGF rs4444903 1.57 1.17–2.11 0.0025 [37] EGF rs9992755 1.45 1.08–1.96 0.014 [37] WNK1 rs11064560 1.41 1.04–1.92 0.028 [37]…
Blood pressure, mmHg NICE 2011 [3] ESH/ESC 2013 [4] AHA/ACC/CDC 2013 [6] ASH/ISH 2013 [5] JSH 2014 [7] JNC 8 [2] Definition of hypertension ≥140/90 and daytime ABPM (or home…
Medication Dosing Special considerations Aspirin Initial dose: 324 mg non-enteric coated chewed at presentation Maintenance dose: 81 mg daily Clopidogrel Initial: 300–600 mg loading dose Maintenance: 75 mg daily Prasugrel…
Definition Criteria for acute myocardial infarction Types Reinfarction Myocardial infarction redefined—a consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction…
Acute coronary syndrome Plaque erosion occurs more frequently in younger women than in men. Unlike in plaque rupture, the plaque in erosion has a thickened fibrous cap and minimal calcification.Women…
