Fig. 28.1 RCT model showing (1) cholesterol efflux, (2) cholesterol esterification by LCAT, and (3) selective hepatic uptake of HDL lipids One approach has been to increase the quality or…
Fig. 62.1 miRNAs are a distinct class of regulatory molecules. MicroRNAs are transcribed from the genome as pri-miRNAs (1) that are processed in the nucleus by a protein complex (2)…
WHO 1 Risk no higher than general population WHO 2 Small increased risk of maternal mortality and morbidity WHO 3 Significant increased risk of maternal mortality and morbidity. Expert cardiac…
Fig. 61.1 Changes in MAP in response to chronic reduced uterine perfusion (RUPP) in pregnant rats and following pretreatment with an ETA receptor antagonist (+ETA) in (a) RUPP and (b)…
Incidence Survival (%) Out-of-hospital [1, 59] 0.5/1000 9 In-hospital [60] 0.17 ± 0.09 per bed/year 17 Cardiac arrest is a time-dependent, dynamic process as conceptualized by Weisfeldt and Becker…
Fig. 17.1 Metabolic changes in advanced heart failure. Cardiovascular diseases such as hypertension, coronary artery disease, cardiomyopathy, and cardiac arrhythmia can lead to heart failure. In end-stage heart failure, typical…
Fig. 39.1 Mechanism of action of methyldopa involving conversion to alpha-methylnorepinephrine and therein stimulation of central α2-adrenoreceptors and a reduction in sympathetic outflow Table 39.1 Pharmacokinetics of centrally acting drugs…
Step 1. Assess and address adherence to therapy Step 2. Rule out measurement error and white-coat effect Step 3. Consider associated comorbidities Step 4. Reconsider secondary causes Step 5. Address…
Fig. 36.1 Ang II-induced G protein-dependent and G protein-independent signal transduction. Ang II signaling through AT1 receptors is coupled to Gαq, activating PLC-β. This leads to generation of IP3 and…
Locus name SNP Chr Position (hg18) Phenotype References CASZ1 rs880315 1 11 Mb SBP/DBP [10] MTHFR-NPPB rs2272803 1 12 Mb SBP/DBP [10] ST7L-CAPZA1-MOV10 rs2932538 1 113 Mb SBP/DBP [10] MDM4…
