Advantages Disadvantages References Maloney-based retrovirus Self-silencing in pluripotent cells, efficient Genomic integration, transduces only dividing cells Takahashi and Yamanaka (2006) Polycistronic retrovirus Only single integration event needed Genomic integration,…
Fig. 1.1 Schematic representation of epithelial cell types found in airways of the adult mouse lung. The adult airway exhibits compartmentalization of constituent cells along the proximal—distal axis. The proximal…
Fig. 3.1 Illustration of potential stem/progenitor cell niches in the lung of the adult mouse. The lung can be divided into three major levels of conducting airways (the trachea, bronchi,…
Fig. 6.1 Tuberculosis. Transbronchial lung biopsy from an elderly individual with cough and weight loss. Cultures grew M. tuberculosis. (a) This ill-defined histiocytic infiltrate is vaguely granulomatous. Compare with Fig….
Usual interstitial pneumonia (UIP) Bronchiolitis obliterans interstitial pneumonia (BIP) Desquamative interstitial pneumonia (DIP) Lymphoid interstitial pneumonia (LIP) Giant cell interstitial pneumonia (GIP) Later, Katzenstein and Askin refined this classification and…
Fig. 8.1 Adenocarcinoma in situ at the interface with normal lung shows an abrupt transition, unlike reactive type II pneumocytes where they blend gradually with normal type I. The cytologic…
Fig. 2.1 Airspace disease due to bacterial pneumonia. (a) Frontal chest radiograph reveals poorly defined lower lobe consolidation (C) with air bronchograms (arrow) and no volume loss indicating an airspace-filling…
Fig 4.1 Low magnification view of the fibrinopurulent exudate in the alveolar space with thickening of the interalveolar septa in (a). A higher magnification of the same pattern shows the…
Fig. 3.1 Low-magnification view of a transbronchial biopsy (left, a) and a cryobiopsy (right, b) for comparison. Notice also the lost tissue from the center of the biopsy due to…
Fig. 7.1 Granular cell tumor with polygonal cells, granular eosinophilic cytoplasm, and uniform small nuclei is usually located under the bronchial mucosa within the endobronchial wall Parenchymatous Tumors While most…
