Ex Vivo Lung Bioengineering
Fig. 8.1 Schematic of ex vivo organ engineering. Autologous cells are obtained by a biopsy from the eventual transplant recipient and expanded in ex vivo culture. A scaffold, either synthetic…
Challenges of Cell Therapy for Lung Diseases and Critical Illnesses
Fig. 6.1 Mechanisms of action of MSCs. MSCs promote benefitial effects through cell-to-cell interactions and through secretion of soluble mediators, microvesicles and whole organelles, that can directly affect many cells,…
The Role of Stem Cells in Vascular Remodeling in CTEPH
© Springer International Publishing Switzerland 2015Amy Firth and Jason X.-J. Yuan (eds.)Lung Stem Cells in the Epithelium and VasculatureStem Cell Biology and Regenerative Medicine10.1007/978-3-319-16232-4_15 15. The Role of Stem Cells in Vascular Remodeling in CTEPH…
Mesothelial Progenitors in Development, Lung Homeostasis, and Tissue Repair
Marker Expression Function Wilm’s tumor1 (WT1) is a zinc finger transcription factor WT1 is expressed in visceral and parietal mesothelial cells, kidney podocytes, and glomerular capillaries WT1 controls organ formation…
The Hope for iPSC in Lung Stem Cell Therapy and Disease Modeling
Advantages Disadvantages References Maloney-based retrovirus Self-silencing in pluripotent cells, efficient Genomic integration, transduces only dividing cells Takahashi and Yamanaka (2006) Polycistronic retrovirus Only single integration event needed Genomic integration,…
Does a Lung Stem Cell Exist?
Fig. 1.1 Schematic representation of epithelial cell types found in airways of the adult mouse lung. The adult airway exhibits compartmentalization of constituent cells along the proximal—distal axis. The proximal…
Stem Cell Niches in the Lung
Fig. 3.1 Illustration of potential stem/progenitor cell niches in the lung of the adult mouse. The lung can be divided into three major levels of conducting airways (the trachea, bronchi,…
Diagnosis of Granulomatous Disease and Vasculitis in Small Lung Biopsies
Fig. 6.1 Tuberculosis. Transbronchial lung biopsy from an elderly individual with cough and weight loss. Cultures grew M. tuberculosis. (a) This ill-defined histiocytic infiltrate is vaguely granulomatous. Compare with Fig….
Interstitial Lung Diseases in Small Lung Biopsies
Usual interstitial pneumonia (UIP) Bronchiolitis obliterans interstitial pneumonia (BIP) Desquamative interstitial pneumonia (DIP) Lymphoid interstitial pneumonia (LIP) Giant cell interstitial pneumonia (GIP) Later, Katzenstein and Askin refined this classification and…
Malignant Tumors of the Lung in Small Lung Biopsies
Fig. 8.1 Adenocarcinoma in situ at the interface with normal lung shows an abrupt transition, unlike reactive type II pneumocytes where they blend gradually with normal type I. The cytologic…
