Target Action/result Complex I ↓ Oxidative phosphorylation → ↓ ATP production ↑ ROS Complex III ↓ Oxidative phosphorylation → ↓ ATP production ↑ ROS Complex IV ↓ Oxidative phosphorylation → ↓ ATP production ↑ ROS Complex…
Fig. 8.1 Mitochondria as oxygen sensor. Mitochondrial reactive oxygen species generation at complex III of the respiratory chain. IMS intermembrane space, SOD superoxide dismutase Mitochondria in Cancer One constitutive metabolic…
Fig. 3.1 Schematic diagram of human mitochondrial genome to show the mtDNA-derived 13 polypeptides, 22 tRNAs (each was named based on respective amino acid), and two rRNAs (12S and 16S)….
Fig. 4.1 Proposed mechanism of blood pressure elevation in patients with OSA Effects of Continuous Positive Airway Pressure (CPAP) on Arterial Hypertension in OSA Patients In OSA patients, nasal CPAP…
Fig. 1.1 Pathway and sites of mitochondrial oxidative phosphorylation and ROS formation. Molecular oxygen is activated at complexes I, II, and III to superoxide anion (O2.−) in the mitochondrial inner…
Fig. 2.1 Regulation of mitophagy and autophagy. Schematic summarizes the p62/SQSTM1-regulated formation of autophagosome for recycling the damaged mitochondria and misfolded and aggregated proteins. Autophagy and mitophagy proceed through several…
Fig. 6.1 ROS-mediated peroxidation of CL forming different molecular species of PUFA hydroperoxides. ROS causes peroxidation of linoleic acid in CL and forms monohydroperoxide and dihydroperoxides on one linoleate ester….
43. Shadel GS, Clayton DA. Mitochondrial DNA maintenance in vertebrates. Annu Rev Biochem. 1997;66:409–35.PubMed 44. Iborra FJ, Kimura H, Cook PR. The functional organization of mitochondrial genomes in human cells….
Fig. 16.1 This schematic places pulmonary vascular cell apoptosis, in particular endothelial cell apoptosis, in the center of the lung vascular remodeling process which results in exuberant wound healing. Autophagy…
Fig. 11.1 Proangiogenic hematopoietic cells may interact with resident endothelial progenitor cells to promote neoangiogenesis. Circulating hematopoietic (bone marrow-derived) cells are proposed to provide paracrine signals that stimulate resident endothelial…
