Non-pharmacological Therapy for IPF
Fig. 11.1 Oxygen time courses in pulmonary capillary when diffusion is normal and abnormal (e.g., because of thickening of the blood–gas barrier by disease) (Reprinted with permission of Wolters Kluwer…
Specific Serum Markers of IPF
Fig. 5.1 Structures of SP-A and SP-D. Monomeric and oligomeric structures of SP-A and SP-D. Monomeric structures can be conceptually divided into four major structural domains: a short N-terminal segment…
Acute Exacerbation of IPF
Fig. 3.1 Clinical disease courses in patients with IPF. The typical natural history of IPF is the slow progression of the disease with a median survival period of approximately 3 years…
Pharmacotherapy of Acute Exacerbation of IPF (Corticosteroids, Immunosuppressants, and Direct Hemoperfusion with Polymyxin)
© Springer Japan 2016Hiroyuki Nakamura and Kazutetsu Aoshiba (eds.)Idiopathic Pulmonary Fibrosis10.1007/978-4-431-55582-7_12 12. Pharmacotherapy of Acute Exacerbation of IPF (Corticosteroids, Immunosuppressants, and Direct Hemoperfusion with Polymyxin) Are High-Dose Steroid Therapy, Other Immunosuppressant Therapy, and PMX Therapy…
Definition of IPF
Fig. 1.1 Diagnostic algorithm for idiopathic pulmonary fibrosis (IPF). Patients with suspected IPF should be carefully evaluated for identifiable causes of interstitial lung disease (ILD). In the absence of an…
Pharmacotherapy of IPF Using Antifibrotic Compounds
Fig. 9.1 Pathogenesis of IPF and the mechanism of action of antifibrotic agents 9.3 Pirfenidone 9.3.1 Mechanism of Action Animal studies have shown that pirfenidone suppresses accumulation of inflammatory cells…
Pathogenesis of IPF
Fig. 4.1 Schematic drawing of the proposed molecular pathogenesis of IPF. AEC, alveolar epithelial cell; EMT, epithelial-mesenchymal transition; ECM, extracellular matrix 4.2 Epithelial Injury and Genetic Background Studies of the…
Epidemiology and Risk Factors of IPF
Fig. 2.1 Alveolar epithelial cells are thought to be the initial lesion of lung injury caused by environmental factors, such as smoking, inhalational agents, drugs, oxygen radicals, toxins, and viruses,…
Differential Diagnosis of IPF
1. IPF is defined as a specific form of chronic, progressive fibrosing interstitial pneumonia of unknown cause, occurring primarily in older adults, limited to the lungs, and associated with the…
Cardiopulmonary Exercise Testing Techniques to Evaluate Exercise Intolerance
and Daniel P. Credeur3 (1) Pediatric Center for Respiratory, Exercise and Sleep Medicine, Athletic Training Facility Football Operations, Louisiana State University, Baton Rouge, LA, USA (2) Louisiana Healthcare Connections, 8585 Archive Blvd…
