Fig. 21.1 The pulmonary hypertension clinical patient care continuum. The Pulmonary Hypertension Clinical (PHC) care coordinator plays a pivotal role in coordinating each element of the treatment plan individualized to…
Fig. 18.1 Example of a potential induction therapy protocol. If a similar protocol were to be transformed into a clinical trial, an additional arm could include dual oral therapy. A…
Fig. 4.1 Group specific prevalence of pulmonary hypertension Temporal trends in mortality and hospitalization where PH was listed as any contributing cause of death or any-listed hospital diagnosis in the…
Biomarker Study endpoints Endothelins Endothelin-1 Hemodynamic measurements, survival Big ET-1 Hemodynamic measurements, 6MWD ET-1/ET-3 Hemodynamic measurements, NYHA FC, survival CT-pro-ET-1 Clinical severity, hospitalizations, survival vWF Hemodynamic measurements, survival Angiopoietin Hemodynamic…
Fig. 10.1 Pulmonary arterial hypertension time-course and type of vascular remodeling pattern secondary to exposure to the monocrotraline pyrrole. A single subcutaneous injection of monocrotaline at a dose of 60…
Fig. 13.1 Left panel: Representative plateau pattern of log-log plot of mPAP vs. VO2 in eiPAH. Right: Representative “take-off” pattern of log-log plot of mPAP vs. VO2 in eiPAH EiPAH…
Fig. 8.1 Metabolic pathways reprogrammed in PAH. Several pathways are affected in humans with and experimental models of PAH. Increased glycolysis, lactate fermentation, and glutaminolysis are observed (purple, pink, and…
Fig. 7.1 The canonical pathway of microRNA processing (Reprinted by permission from Macmillan Publishers Ltd: Winter et al. [97] Nature Publishing Group) Computational Biology, Our Venue to Understand MicroRNA Network…
Date/time range Key figure/event Contribution 1628 William Harvey Publication of his book Exercitatio Anatomica de Motu Cordis et sanguinis in Animabilus 1891 Ernst von Romberg Description of abnormal findings in…
Compost White-collar workers (controls) Current workers Former workers n 140 49 29 Gender, male (n%) 135 (97 %) 44 (92 %) 28 (97 %) Age (year; mean ± SD) 45 ± 9.1 51 ± 10.3 57 ± 6.5 sx1-pos (atopics)…
