Fig. 57.1 Schematic representation of heart development in mice (upper row) and hypothetical depiction of factors leading to HLHS, as summarized from the literature (for references, see text). Abbreviations: OFT…
© Springer-Verlag Wien 2016Silke Rickert-Sperling, Robert G. Kelly and David J. Driscoll (eds.)Congenital Heart Diseases: The Broken Heart10.1007/978-3-7091-1883-2_56 56. Human Genetics of Hypoplastic Left Heart Syndrome Woodrow D. Benson1 (1) Department of Pediatrics, Herma Heart Center, Children’s Hospital…
Fig. 55.1 Diagrammatic representation of HLHS. On the left is aortic valve atresia and on the right is mitral valve atresia. Note the hypoplastic left ventricle in both cases. Abbreviations:…
Fig. 19.1 An illustration of the location of atrial septal defects (ASD). The left panel is a pathological specimen of a normal heart with the anterior surface of the heart…
Chromosomal disorder Number of patients reported Proven or suspected causal gene(s) References Deletion 1p36 9 DVL1, SKI, RERE, PDPN, SPEN, CLCNKA, ECE1, HSPG2, LUZP1, WASF2, PRDM16, PRKCZ, UBE4B, MASP2 [12,…
Fig. 52.1 Pathologic specimen of Ebstein anomaly (left) and echocardiographic image (right). The septal leaflet is plastered against the septum (failure of delamination), and the anterior leaflet is markedly enlarged…
Fig. 49.1 Illustration of the modified extracardiac Fontan operation. The superior vena cava has been disconnected from the right atrium and anastomosed to the right pulmonary artery. A graft has…
Fig. 47.1 Cellular and molecular basis for normal and abnormal outflow tract development of the heart. The interaction of progenitor cells derived from the second heart field (SHF cells) and…
Fig. 46.1 Diagrammatic representation of normal circulation (right panel) and truncus arteriosus (left panel). Note that in truncus arteriosus, there is only one semilunar valve and this is referred to…
Fig. 45.1 Normal and abnormal coronary anatomy. Cartoons illustrate normal (1–3) coronary anatomy and relevant cases of coronary congenital anomalies (4–9). Asterisks indicate the specific location of myocardial bridges (7b),…
