Patient characteristics Risk score Site of cancer Very high risk (stomach, pancreas) High risk (lung, lymphoma, gynecologic, bladder, testicular) 2 1 Prechemotherapy platelet count 350,000/mm3 or more 1 Hemoglobin level…
Fig. 1.1 Age-adjusted death rates for heart disease and cancer in the United States, 1980–2011 Cancer and Cardiovascular Disease: Convergent Epidemiology Many of the risk factors for cardiovascular disease (e.g.,…
Agents Drug class Cancer clinical use Type of cardiotoxicity Frequency Chemotherapeutic agents Doxorubicin Anthracyclines Breast, sarcoma, lung, bladder, gastric, prostate, leukemia, lymphoma, others LV dysfunction Common Epirubicin Anthracyclines Breast, esophageal,…
Fig. 8.1 Comparison of age specific death rates for malignancy and cancer, showing that their effects are similar as patients age. Both diseases are more common with advancing age. In…
Class of chemotherapy Examples Anthracycline Daunorubicin Doxorubicin Epirubicin Mitoxantrone Alkylating agents Cyclophosphamide Cisplatin Microtubule-targeting agents Paclitaxel Docetaxel Topoisomerase II inhibitors Etoposide Biologic response modifiers Interferon Interleukin-2 Antimetabolites Fluorouracil Antibodies Trastuzumab…
Fig. 13.1 Overview of the spectrum of cardio-oncology: bench to bedside to community. Partnerships across and within the disciplines of cardiology and oncology in the areas of research (basic, translational,…
Fig. 12.1 The “snowball effect” leading to cardiovascular complications of breast cancer therapy in older patients. Reproduced with permission from Shenoy et al. [6] In order to help care for…
Risk Assessment : An Overview For left ventricular systolic dysfunction, we propose an approach that incorporates the ACC/AHA staging when evaluating and managing the care of cancer survivors. It is…
DRUG Toxic dose range Cardiac toxicity % Doxorubicin Epirubicin >450 mg/m2 >900 mg/m2 Left venticular dysfunction 3–12% 0.9–3.3% Paclitaxel Docetaxel Conventional dose Left venticular dysfunction 5–15% 2.3–8% Cyclophosphamide >100–120 mg/kg Left venticular dysfunction…
Classification Systolic BP (mmHg) Diastolic BP (mmHg) Normal <120 <80 Prehypertension 120–139 80–89 Stage 1 140–159 90–99 Stage 2 >160 >100 Within oncology, the Common Terminology Criteria for Adverse Events…
