WATCHMAN: Trials and Registries Results
Fig. 11.1 WATCHMAN clinical trial program Pilot Feasibility Study This was the first initial worldwide experience with the WATCHMAN device, which consisted of 75 patients enrolled in three European and…
Conventional Surgery for LAA Closure
Fig. 5.1 Normal heart anatomy with trabeculated left atrial appendage A review of the literature elucidates that 70 % of all strokes in patients with AF are cardioembolic in nature…
Antiplatelet and Anticoagulant Strategies Following Left Atrial Appendage Closure
Fig. 19.1 Thrombus seen on CT image of Watchman device (Courtesy of J. Saw) As the only randomised study in the field to date, detailed analysis of the data from…
Efficacy and Limitations of Warfarin and Novel Oral Anticoagulants with Atrial Fibrillation
National Guidelines Organization Stroke risk CCS [12] ESC [11] AHA/ACC/HRS [14] ACCP [13] High Age > 65, or any CHADS2 risk factor CHA2DS2-VASc ≥ 1 CHA2DS2-VASc ≥ 2 CHADS2 ≥ 1 OAC OAC OAC OAC Low Age < 65,…
Concomitant Left Atrial Appendage Closure and Catheter Ablation of Atrial Fibrillation
Patients (n = 35) Age (years) 72 ± 4 Male subjects 28/35 (79 %) AF history (months) 66 ± 36 Paroxysmal AF (%)/Persistent AF (%) 28 (80 %)/7 (20 %) LV ejection fraction, % 54 ± 7…
LARIAT: Trials and Registries Results
Study Attempted/total screened Acute LAA closure Persistent LAA closure Stroke Bleeding Pericardial bleeding drained Emergency surgery Pericarditis Late pericardial effusion Death LAA stump thrombus Pleural effusion N % N %…
ACP and Amulet: Trials and Registries Results
Fig. 13.1 Comparison between the Amplatzer Cardiac Plug and the Amulet. Comparison between the ACP (left) and the Amulet (right) highlighting the increased number of stabilizing wires (a), the inversion…
Mechanistic Rationale for LAA Closure with AF and Stroke Prevention
Setting No. of patients Thrombus location Reference no. LA appendage LA cavity Operation 581 26 17 [16] Autopsy 136 12 11 [17] Operation 818 20 23 [18] TEE 50 12…
Atrial Fibrillation and Stroke Epidemiology
CHADS2 risk criteria Score Prior stroke or TIA 2 Age >75 years 1 Hypertension 1 Diabetes mellitus 1 Heart failure 1 Patients (N = 1733) Adjusted stroke rate (%/y)a (95% CI) CHADS2…
Echocardiographic Assessment of Functional Ischaemic Mitral Regurgitation
Fig. 3.1 (a) Dilatation of the basal inferior wall (yellow arrow a) as a result of myocardial infarction. (b) Jet of anteriorly-directed MR (yellow arrow b) resulting from restriction of…
