Outline Overview of Innate Immunity, 103 Expression and Regulation of Pattern Recognition Receptors in the Heart, 103 Toll Receptors, 103 Role of Toll-like Receptors in Myocardial Disease, 106 Toll-like Receptor…
Outline A Perspective on the Renin Angiotensin Aldosterone System, 76 The Biochemical Physiology of the Renin Angiotensin System, 76 Renin and Pro-Renin, 79 Other Nonrenin Enzymes, 79 Angiotensinogen, 79 Angiotensin…
Outline Role of Increased Adrenergic Drive in the Natural History of Heart Failure, 91 Adrenergic Receptor Pharmacology, 93 Altered β-Adrenergic Receptor Signal Transduction in the Failing Heart, 94 Molecular Basis…
Outline Myocardial Extracellular Matrix Structure and Composition, 63 The Myocardial Fibroblast, 63 Myocardial Extracellular Matrix Proteolytic Degradation: The Matrix Metalloproteinases, 64 Transcriptional Regulation of Extracellular Matrix Degradation; Matrix Metalloproteinase Polymorphisms,…
Outline Types of Heart Failure, 1 HFrEF Versus HFpEF: Ramifications for Understanding the Underlying Biology, 1 Investigative Techniques and Molecular Modeling, 2 Molecular Determinants of Physiologic Cardiac Growth, Hypertrophy, and…
Outline Contractile Dysfunction, 30 Normal Excitation-Contraction Coupling, 31 Impaired Ca 2+ Handling in Failing Cardiac Myocytes, 31 Reduced SR Ca 2+ Reuptake in Heart Failure, 32 Increased NCX Activity in…
Transcatheter aortic valve replacement Since the first transcatheter bioprosthetic aortic valve was implanted, changes have included smaller and more flexible delivery systems for use in smaller vessels; lower frame height…
Pseudoaneurysms CASE 10-1 Aortic pseudoaneurysm after avr with anterior extension This 41-year-old man with Reiter’s syndrome underwent mechanical aortic valve replacement 9 years ago for aortic regurgitation. Four months ago…
Atrial septal defects CASE 7-1 Anatomy and imaging of the atrial septum The atrial septum is close to the TEE transducer position and is well visualized, as the normal orientation…
Atrial septum CASE 14-1 Anatomy and imaging of atrial septum See Case 7-1 in Chapter 7 , Adult Congenital Heart Disease. CASE 14-2 PFO device closure for recurrent transient neurological…
