Arrhythmia Genomics
Abstract Abnormalities of cardiac rhythm are important causes of cardiovascular disability, stroke, and sudden cardiac death. Two general approaches have been used to identify genes playing a role in arrhythmia…
Genetics and Genomics of Peripheral Arterial Disease
Abstract Advances in mouse and human genome research have dramatically altered the landscape and pace of advances in the diagnosis and treatment and many diseases. Peripheral arterial disease (PAD) is…
Heart Failure: Impact of Genetics and Genomics
Abstract This chapter focuses on the impact of genetics and genomics on heart failure. Part one outlines how genetics provides insight to the underpinnings of heart failure. Part two highlights…
Genomics-Guided Antithrombotic Therapy for Acute Coronary Syndromes
Abstract A substantial burden of cardiovascular disease results from thrombosis that manifests clinically as acute coronary syndrome, stroke, and venous thromboembolism. Although antithrombotic drugs that inhibit platelets and coagulation factors…
Genetic Basis of Congenital Heart Disease
Abstract Congenital heart disease (CHD) is the most common birth defect. Despite considerable advances in care, CHD remains a major contributor to newborn mortality and is associated with substantial morbidities…
Hypertrophic Cardiomyopathy in the Era of Genomic Medicine
Abstract Hypertrophic cardiomyopathy (HCM) is a relatively common, primary disorder of the myocardium characterized by unexplained left ventricular hypertrophy affecting perhaps as many as 1 in 500 people. HCM is…
Hypertension
Abstract Hypertension is heritable and is a major global health problem. Identifying genetic variants contributing to the disorder has been challenging, but from 2009, there have been significant advances in…
Novel Approaches to Cardiovascular Diagnostics: Focus on Coronary Artery Disease and Myocardial Infarction
Abstract There is a significant unmet need in the diagnosis and prediction of coronary artery disease (CAD) and subsequent major adverse cardiovascular events including myocardial infarction. Recently, a number of…
Metabolic Syndrome
Abstract Metabolic syndrome (MetS) is the commonly observed clustering of obesity, hypertension, dyslipidemia, and insulin resistance. The components of MetS occur together more often than expected by chance and display…
Lipoprotein Disorders
Abstract Plasma levels of triglycerides (TGs), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) are highly heritable traits. The study of their human genomics has identified >150 genes that…
