Summary of Key Points • Humoral and cellular immune dysregulation in the tumor microenvironment contributes to immune evasion, a key hallmark of lung cancer. • Immunosuppressive mechanisms observed in lung…
Summary of Key Points • The biologic roles of microRNAs (miRNAs) in lung cancer indicate their correlation with disease status, prognosis, and therapeutic outcome. The discovery of miRNAs has opened…
Summary of Key Points • There is untapped potential for targeted lung cancer prevention and therapy that requires, as a first step, a more clear delineation of the biology underlying…
Abstract There have been recent advances in isolation and characterization of the putative cells of origin associated with non-small cell lung cancer and small cell lung cancer. Key biochemical pathways…
Abstract Noninvasive biomarkers in the blood, sputum, airway epithelium, or exhaled breath can be combined with imaging to detect early-stage lung cancer and improve mortality. Lung cancer biomarkers may reduce…
Keywords chemoprevention, CT screening, early detection, lung cancer, smoking cessation Summary of Key Points • Most chemoprevention research is focused on natural products and is not amenable to traditional…
Keywords early detection, lung neoplasms, screening Summary of Key Points • The National Lung Screening Trial has definitively shown a reduction in lung cancer mortality in a research setting…
Abstract Evidence for the role of genetic susceptibility to lung cancer is substantial even while 85% to 90% of lung cancer is attributable to cigarette smoking. Studies demonstrate familial aggregation…
Abstract Tobacco is the single greatest contributor to development of lung cancer. Nearly all societies across the globe are afflicted with the tobacco epidemic, and smoking rates are rising for…
Abstract Major clinical, ethnic, gender, and histology differences between lung cancers arising from smokers and never-smokers, coupled with their different etiologic factors and major molecular differences, indicate that they represent…
