Fig. 9.1 Conceptual approach to overall study design for genomic assessment of genetic variants, transcriptome, and epigenetic marks in which internal (technical) and external (replication) validation are performed to ensure validity…
© Springer International Publishing AG 2017Lynn M. Schnapp and Carol Feghali-Bostwick (eds.)Acute Lung Injury and RepairRespiratory Medicine10.1007/978-3-319-46527-2_3 3. Transgenic Animal Models in Lung Research Chi F. Hung1 and William A. Altemeier1 (1) Division of Pulmonary and Critical Care Medicine,…
Fig. 1.1 Typical ARDS chest radiograph showing bilateral, patchy infiltrates. Courtesy of Dr. Andrew Goodwin, MUSC ARDS Pathogenesis ARDS is characterized as an acute diffuse, inflammatory lung injury, leading to increased…
Marker Targeted cell population Reference Negative selection Depletion of unwanted cell populations CD45 Differentiated hematopoietic cells, except erythrocytes and platelets [22, 27, 28, 38] CD16/32 Macrophages, monocytes, B-cells, NK…
(1) Kantonsspital Aarau, Medizinische Universitätsklinik, Aarau, Switzerland KeywordsLV-afterloadPreloadTransmural LVEDPLV end-diastolic pressure (LVEDP)Stroke volumeLV end-diastolic volume (LVEDV)Pericardial pressure (PP)Central venous pressure (CVP)Cardiac output (CO)Fluid responsivenessFluid challengeExtravascular lung water (EVLW)AutoregulationTissue hypoperfusionLV…
(1) Kantonsspital Aarau, Medizinische Universitätsklinik, Aarau, Switzerland KeywordsHeterometric adaptionHomeometric adaptionDiastolic ventricular interaction (interdependence)RV end-diastolic pressure (RVEDP)RV end-diastolic volume (RVEDV)Pulmonary vascular resistance (PVR)RV afterloadSeries-effectPulmonary hypertensionPulmonary vasculopathyPulmonary pressurePulmonary embolismRV contractilityRV enlargement/dilationMechanical…
(1) Kantonsspital Aarau, Medizinische Universitätsklinik, Aarau, Switzerland KeywordsDiastolic dysfunction (DD)Heart failure with preserved ejection fraction (HFpEF)Heart failure with reduced ejection fraction (HFrEF)Diastolic (ventricular) propertiesSystolic (ventricular) propertiesHypertensive heart diseaseStiffened arterial…
(1) Kantonsspital Aarau, Medizinische Universitätsklinik, Aarau, Switzerland KeywordsPulmonary edemaNeurohormonal activationSystemic congestionPulmonary congestionHemodynamic congestionClinical congestionInflammationEndothelial dysfunctionNO bioavailabilityVentriculo-arterial stiffeningCardiac performanceVacular toneVascular stiffnessVascular failureCardiac/cardio-renal failureRedistributionFluid accumulationVenous capacitanceBlood pressure (BP)Hemodynamic profilesDiureticsVasodilatorsInotropic drugs 2.1…
(1) Kantonsspital Aarau, Medizinische Universitätsklinik, Aarau, Switzerland KeywordsHypoperfusionAcute myocardial infarction (AMI)Systemic inflammatory response (SIRS)Inappropriate vasoconstrictionMicrocirculationNeuro-endocrine activation (reply)Myocardial contractilityMean arterial pressure (MAP)AutoregulationHypotensionPercutaneous coronary intervention (PCI)VasopressorsInotropic drugs 3.1 Definition Shock is…
(1) Kantonsspital Aarau, Medizinische Universitätsklinik, Aarau, Switzerland KeywordsDiuretic resistanceCardio-renal cross-talkIntrarenal and intraglomerular hemodynamicsRenal perfusion/blood flowRenal hypoperfusionRenal autoregulation/impaired (altered) renal autoregulationMicrovascular dysregulationRenal venous pressureSystemic venous congestionRenal venous congestionNeurohormonal activationEndothelial dysfunctionRenal…
