Fig. 12.1 The pulmonary arterial vascular tree. The pulmonary arterial circulation is characterized by a gradual loss of complexity and muscularization from proximal to distal branches of the vascular tree…
Fig. 5.1 Human cells are found in the lungs of bleomycin-treated mice after transplantation with hES cells differentiated into lung lineage-specific cells. 3,3′-Diaminobenzidine (DAB) immunocytochemistry using anti-human nuclear factor antibody…
Fig. 8.1 Schematic of ex vivo organ engineering. Autologous cells are obtained by a biopsy from the eventual transplant recipient and expanded in ex vivo culture. A scaffold, either synthetic…
Fig. 6.1 Mechanisms of action of MSCs. MSCs promote benefitial effects through cell-to-cell interactions and through secretion of soluble mediators, microvesicles and whole organelles, that can directly affect many cells,…
© Springer International Publishing Switzerland 2015Amy Firth and Jason X.-J. Yuan (eds.)Lung Stem Cells in the Epithelium and VasculatureStem Cell Biology and Regenerative Medicine10.1007/978-3-319-16232-4_15 15. The Role of Stem Cells in Vascular Remodeling in CTEPH…
Marker Expression Function Wilm’s tumor1 (WT1) is a zinc finger transcription factor WT1 is expressed in visceral and parietal mesothelial cells, kidney podocytes, and glomerular capillaries WT1 controls organ formation…
Advantages Disadvantages References Maloney-based retrovirus Self-silencing in pluripotent cells, efficient Genomic integration, transduces only dividing cells Takahashi and Yamanaka (2006) Polycistronic retrovirus Only single integration event needed Genomic integration,…
Fig. 1.1 Schematic representation of epithelial cell types found in airways of the adult mouse lung. The adult airway exhibits compartmentalization of constituent cells along the proximal—distal axis. The proximal…
Fig. 3.1 Illustration of potential stem/progenitor cell niches in the lung of the adult mouse. The lung can be divided into three major levels of conducting airways (the trachea, bronchi,…
Fig. 6.1 Tuberculosis. Transbronchial lung biopsy from an elderly individual with cough and weight loss. Cultures grew M. tuberculosis. (a) This ill-defined histiocytic infiltrate is vaguely granulomatous. Compare with Fig….
