(1) University of Ottawa The Ottawa Hospital, Ottawa, ON, Canada There are important, subtle differences among the available calcium antagonists that may affect the choice in treating individual patients….
(1) University of Ottawa The Ottawa Hospital, Ottawa, ON, Canada ACE Inhibitors Versus ARBs: Does the Choice Matter? Angiotensin-converting enzyme (ACE) inhibitors have been shown in large randomized controlled…
(1) University of Ottawa The Ottawa Hospital, Ottawa, ON, Canada Calcium Antagonists Cause an Increased Incidence of HF and MI: True or False? Calcium antagonists without doubt cause an…
Fig. 12.1 The ubiquitin-proteasome system and steps in the ubiquitylation and degradation of cellular substrate proteins. The ubiquitin and 26S proteasome structures were adopted from Vijay-Kumar et al. (1987) and…
Fig. 3.1 (a) Changes of length and width of mouse cardiomyocytes during growth. Birth day set as 0. Data from embryonic day 8.5 (−11.5) to 4 days after birth taken…
Fig. 9.1 The nuclear envelope and the nuclear lamina. The nuclear envelope provides a physical barrier for nuclear compartmentalisation and a platform for communication between the nucleus and cytoskeletal domains…
Fig. 7.1 Schematic representation of a sarcomere with a scheme showing its main molecular constituents below. Myosin is represented in blue, titin in red and the M-band in purple. Dashed…
Fig. 4.1 Cardiac Sarcomere. The sarcomere is the basic contractile unit of muscle. The lateral boundaries of a sarcomere are defined by protein-dense Z-discs. The I-band is the region surrounding…
Fig. 10.1 AMPK structure. (a) AMPK domain structure of the three AMPK subunits (SID, subunit interaction domains; AID, autoinhibitory domain; CBM, carbohydrate-binding module; CBS, cystathionine-β synthase). (b) AMPK complex topology….
Fig. 2.1 The multi-scale structure of the heart. The function of the heart is dependent on its hierarchical architecture, which spans organ, tissue, cellular, and molecular levels 2.1 Structure–Function Relationships…
