Right Ventricular Enlargement
Gregory Kicska, MD, PhD
DIFFERENTIAL DIAGNOSIS
Common
Left Heart Failure
Secondary Pulmonary Hypertension
Right Heart Failure
Less Common
Left to Right Shunt
Right Heart Valvular Disease
Primary Pulmonary Arterial Hypertension
Rare but Important
Arrhythmogenic Right Ventricular Dysplasia
Congenital Heart Disease
D-transposition of Great Vessels with Atrial Switch
Tetralogy of Fallot (TOF) with Pulmonic Regurgitation or Stenosis
ESSENTIAL INFORMATION
Key Differential Diagnosis Issues
Quantitative determination of right ventricle dilation
Normal end diastolic volume = 75 ± 13 mL/m2 for adolescent to adult
Volumes best measured with bright-blood cine MR in axial or short axis plane or retrospectively gated CT
Radiographic signs of RV dilation
Leftward displacement and flattening of left heart contour on frontal view
Filling of retrosternal clear space and posterior displacement of left ventricle on lateral view
Flattening of interventricular septum only during diastole suggests volume overload
Flattening of interventricular septum during systole and diastole suggests pressure overload with or without volume overload
Quantitative determination of right ventricular hypertrophy
Wall thickness > 5 mm suggests hypertrophy
Normal right ventricular free wall mass = 26 ± 5 g/m2
Helpful Clues for Common Diagnoses
Left Heart Failure
Ischemic cardiomyopathy and diabetes mellitus most common
Multi-vessel coronary artery calcifications/disease
LV and LA enlargement
Pulmonary edema
Prior myocardial infarction, LV delayed enhancement, or LV endomyocardial fat
Diastolic heart failure more commonly associated with elevated LA pressure
Secondary Pulmonary Hypertension
Main pulmonary artery > 2.8 cm if < 50 years, main pulmonary artery:ascending aorta ratio > 1 if > 50 years
RV mass/(LV + septum mass) > 0.6 suggests pulmonary hypertension
MR delayed contrast enhancement at RV wall insertion into interventricular septum
Suspect if interstitial lung disease, chronic obstructive pulmonary disease, or chronic pulmonary embolism
Suspect if mitral valve stenosis present
Calcified mitral valve leaflets
High flow jet on MR vertical long axis cine
Left atrial dilation
MR short axis mitral valve area < 2.5 cm on cine and elevated peak velocity on through plane phase contrast
Cardiac masses, such as atrial myxoma, can cause valve occlusion
Right Heart Failure
Markedly enlarged RV with relatively normal LV
Right atrial enlargement
Enlarged IVC/SVC and ascites
Ischemic cardiomyopathy suggested by proximal right coronary artery occlusive disease or left circumflex disease when left-dominant coronary anatomy present
Helpful Clues for Less Common Diagnoses
Left to Right Shunt
Atrial septal defect (ASD)
2nd most common left to right shunt but most likely to cause dilated RV
Coexistent RA enlargement
MR bright-blood cine short axis or 4-chamber stack without skip throughout interatrial septum may show flow jet
Large ASD may not show flow jet on bright-blood cine
MR phase contrast determines main pulmonary artery:aorta flow > 1
In cases of sinus venous ASD, look for partial anomalous pulmonary venous return
Ventricular septal defect (VSD)
Most common left to right shunt but often not hemodynamically significant or spontaneously closes by adulthood
Best investigated with methods similar to ASD
Right Heart Valvular Disease
Valvular calcifications indicate stenosis or regurgitation
Phase contrast MR to determine pressure gradients and regurgitant fractions most helpful
Isolated enlargement of left pulmonary artery suggests pulmonary stenosis
Primary Pulmonary Arterial Hypertension
Pulmonary artery > 25 mmHg, pulmonary capillary wedge pressure < 15 mmHg, pulmonary vascular resistance > 2.4 mN x s/cm5
Absence of secondary cause of pulmonary hypertension
Distinction between primary and secondary causes is critical because therapeutic pulmonary vasodilators are deleterious in secondary causes
Imaging findings suggesting primary pulmonary hypertension
Normal lung volumes and parenchyma
Normal left heart size and absence of valvular calcifications
Helpful Clues for Rare Diagnoses
Arrhythmogenic Right Ventricular Dysplasia
Diagnosis requires presence of sufficient major and minor criteria, many of which are not related to imaging
Major imaging criteria: Severe RV dilation, localized RV aneurysms, fibrofatty replacement of myocardiumStay updated, free articles. Join our Telegram channel
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