The study by Minhas et al, published online ahead of print on July 15, 2015, in the Journal on the nationwide trends in the reported incidence of takotsubo syndrome (TTS) from 2006 to 2012, provides an opportunity for evaluation of the pathophysiological underpinning of this enigmatic disease. The investigators have documented an increasing incidence of TTS, as a principal diagnosis, in the United States using discharge data from the Nationwide Inpatient Sample, created by the Agency for Healthcare Research and Quality, for each of the years from 2006 to 2012, with estimated cases of patients stratified by 4 age groups and gender, that has burgeoned 20-fold (315 cases ± 43 [SE] in 2006 and 6,230 cases ± 232 [SE] in 2012 [p <0.001 for trend]), which they have attributed to an increasing recognition of TTS. It has been recently reported that the prevalence of diabetes mellitus (DM) in patients with TTS is low, and this may have pathophysiological connotations. TTS has been thought to be due to a central sympathetic nervous system and/or catecholamine release surge, and thus, DM with its underlying peripheral neuropathy (including autonomic neuropathy) may exert a “blocking” effect for the emergence of TTS. The present study provides a marvelous opportunity, albeit the data limitations discussed by the investigators, to prove or refute this hypothesis, for women versus men, and for the age groups of 18 to 44, 45 to 64, 65 to 84, and ≥85-year-old patients with TTS. All that is needed is to provide the estimated incidence of DM and hypertension for all TTS patients, women and men, for the earlier mentioned 4 age brackets, and for the 7 years from 2006 to 2012. The focus of the idea is to use the prevalence of DM in the patients diagnosed with TTS and the prevalence of hypertension to ensure that the patients with TTS was representative of the general population. It is expected that the prevalence of DM and hypertension will not vary from 2006 to 2012, among the patients with TTS, and this (if found) may provide further support for the theory linking TTS with low prevalence of DM.