Background
Non-dipper hypertension is associated with increased cardiovascular morbidity and mortality. Mean platelet volume( MPV) is accepted as an indicator of platelet activation and higher thrombotic potential. Our purpose is to evaluate the relation of mean platelet volume(MPV), dipper and non-dipper newly diagnosed hypertensives and normotensives.
Material and Method
A total of 103 subsequent newly diagnosed hypertension patients and 34 normotensive healthy subjects were enrolled according to office and home blood pressure measurements. Then hypertensive patients went on 24-hour ambulatory blood pressure measurements. Dipper and non-dipper hypertensive patients and normotensives were compared according to basic characteristics, MPV and platelet count. Non-dipper hypertensive group included 62 patients (30 males; 57,9±10,7yrs) and dippers included 41 patients (23males; 57±11,9 yrs), normotensives included 34 healthy subjects(15 males, 53,4±9,6 yrs). Differences in serum biochemical and hematological parameters were compared between groups.
Material and Method
A total of 103 subsequent newly diagnosed hypertension patients and 34 normotensive healthy subjects were enrolled according to office and home blood pressure measurements. Then hypertensive patients went on 24-hour ambulatory blood pressure measurements. Dipper and non-dipper hypertensive patients and normotensives were compared according to basic characteristics, MPV and platelet count. Non-dipper hypertensive group included 62 patients (30 males; 57,9±10,7yrs) and dippers included 41 patients (23males; 57±11,9 yrs), normotensives included 34 healthy subjects(15 males, 53,4±9,6 yrs). Differences in serum biochemical and hematological parameters were compared between groups.
Results
No statistically meaningful difference was detected between groups according to basic characteristics. All 24-hour diastolic and systolic blood pressures, day and night-time diastolic and systolic blood pressures were significantly higher in non-dipper patients. MPV was significantly higher in non-dippers(11±7,4fl) than dippers(10,2±1,9 fl) and normotensives(9,6±1 fl) (p<0,05 and p<0,05) respectively.
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