Background
Contrast-induced nephropathy (CIN) is described as acute renal damage developed secondary to contrast media (CM) exposure and is associated with prolonged hospital stay and adverse clinical outcome. In recent studies, Monocyte to high-density lipoprotein ratio (MHR) has been postulated as a novel parameter related with adverse renal and cardiovascular outcomes. In this study we investigated the association of MHR with CIN in ST segment elevation myocardial infarction (STEMI) patients treated with primary percutaneous coronary intervention (PCI).
Methods
Consecutive STEMI patients treated with primary PCI were prospectively recruited. Subjects were categorized into two groups; as patients who developed CIN (CIN+) and patients who did not develop CIN (CIN-) during hospitalization. Contrast induced nephropathy was defined as either a 25% increase in serum creatinine from baseline or 0.5 mg/dL increase in absolute value, within 72 hours of intravenous contrast administration.
Methods
Consecutive STEMI patients treated with primary PCI were prospectively recruited. Subjects were categorized into two groups; as patients who developed CIN (CIN+) and patients who did not develop CIN (CIN-) during hospitalization. Contrast induced nephropathy was defined as either a 25% increase in serum creatinine from baseline or 0.5 mg/dL increase in absolute value, within 72 hours of intravenous contrast administration.
Results
A total number of 209 patients were included in the study. Thirty-two patients developed CIN (15.3%). In the CIN (+) patients, monocytes were higher (1.02 [0.83-1.39] vs. 0.69 [0.53-0.90] 103/μL, p <0.01) and HDL cholesterol levels were lower (34.3 ± 6.1 vs. 38.4 ± 7.5 mg/dL, p <0.01) (Table 1). In addition, MHR was significantly higher in the CIN (+) group (3.01 [2.30-4.19] vs. 1.87[1.38-2.47] 106/mg, p < 0.01) (Table 1). In multivariate logistic regression analysis, MHR (OR 2.19 95% CI 1.28-3.77, p < 0.01), total contrast volume, age, left ventricular ejection fraction, fasting glucose levels were independently correlated with CIN.
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