Pneumatocele
Eric J. Stern, MD
DIFFERENTIAL DIAGNOSIS
Common
Traumatic Pneumatocele
Postinfectious Pneumatocele
Bullous Emphysema
Paraseptal Emphysema
Tuberculosis
Less Common
Lung Abscess
Rare but Important
Hydrocarbon Aspiration
ESSENTIAL INFORMATION
Key Differential Diagnosis Issues
Proper history of trauma or prior infection is paramount
Helpful Clues for Common Diagnoses
Traumatic Pneumatocele
Result from laceration of lung tissue
Penetrating injury; stab wound, gunshot wound
Blunt injury
Small, peripheral lacerations from overlying rib fractures
Paravertebral lacerations from shearing injury
Central lacerations from compression rupture; larger and more irregular in shape
Often initially obscured by surrounding pulmonary contusion/hemorrhage
Can initially present filled with blood (hematoma); fills with air as blood clears
Resolve/heal without treatment over 1-2 weeks
Postinfectious Pneumatocele
Common after Staphylococcus and Coccidioides infections
Thin walled
Pneumatocele can persist for years
Bullous Emphysema
Underlying centrilobular emphysema
Emphysematous spaces > 1 cm
Paraseptal Emphysema
Peripheral lung along fissures and sharp pleural reflections
Tuberculosis
Other features of nodular scarring, bronchiectasis, volume loss, ipsilateral tracheal deviation
Typically unilateral, upper lobe/apical
Helpful Clues for Less Common Diagnoses
Lung Abscess
Patients more acutely ill; fever, cough, chest pain
Ill-defined walls
Air-fluid levels common
Helpful Clues for Rare Diagnoses
Hydrocarbon Aspiration
Rare complication of unintended hydrocarbon inhalation or aspirationStay updated, free articles. Join our Telegram channel
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