Paclitaxel-coated balloon study: quantitative coronary angiography and optical coherence tomography evaluation in a swine in-stent stenosis model




Background


Drug-coated balloons (DCBs) have shown efficacy for treatment of coronary artery disease. In the PEPCAD II ISR trial, paclitaxel-coated balloon (PCB) reduced in-stent restenosis (ISR) compared with paclitaxel-eluting stent (PES). Here we evaluated the efficacy of PCB in a porcine ISR model.




Materials and methods


Thirty-two coronary arteries (LAD: n =12, LCX: n =11, RCA: n =9) of 24 Yorkshire pigs were assigned to two groups randomly. PCB (SeQuent, length 20 mm, n =16) or noncoated balloon (NCB, length 20 mm, n =16) was inflated for 60 s with B:A 1.2:1 followed by BMS (length 12 mm) implantation (S/A 1.5:1) within the target region. At 28 days, animals underwent restudy for the assessment of quantitative coronary angiography (QCA) and optical coherence tomography (OCT).

Only gold members can continue reading. Log In or Register to continue

Related posts:

  1. Coronary stenting with MGuard: extended follow-up of first human trial
  2. Understanding the impact of drug-eluting stent on vascular function and the nitric oxide pathway genes using a pig coronary artery stent implantation model
  3. Statin improves outcome of patients presenting with first acute myocardial infarction
  4. Risk factors and impact of contrast left ventriculogram on incidence of contrast-induced nephropathy: is left ventriculogram really necessary?

Stay updated, free articles. Join our Telegram channel
Tags:
Nov 16, 2017 | Posted by in CARDIOLOGY | Comments Off on Paclitaxel-coated balloon study: quantitative coronary angiography and optical coherence tomography evaluation in a swine in-stent stenosis model

Full access? Get Clinical Tree
Get Clinical Tree app for offline access