Objective
Renal function and aortic stiffness have significant interaction and even valid in patients with normal or mildly impaired renal function. Several modalities such as distensibility coefficient, augmentation index and aortic pulse wave velocity have been evaluated for aortic stiffness assessment. Central aortic pulsatility (fractional pulse pressure), derived from direct measurement of ascending aortic systolic and diastolic blood pressures, is an invasive modality for aortic stiffness assessment. Although this modality is not feasible for bulk community scanning for aortic stiffness, it is easy to assess and free of additional costs in patients undergoing invasive catheterization with other indications. We aimed to investigate the possible association between aortic stiffness evaluated by central aortic pulsatility and estimated glomerular filtration rate in population with coronary artery disease and without overt renal disease.
Methods
We evaluated 72 patients (44 male; 28 female; mean age of 59.0 ± 10.3 years) with coronary artery disease(at least one cornary artery with ≥50 % lesion). Estimated glomerular filtration rate (eGFR) of each patient was calculated with dividing Cockcroft-Gault formula by body surface area. Direct measurements of aortic blood pressures were utilized to calculate pulse pressure and fractional pulse pressure (ratio of aortic pulse pressure to aortic mean pressure).
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