Objective

Vitamin D deficiency is associated with coronary artery disease (CAD) and cardiac mortality. However, the mechanism of increased cardiac mortality in patients with vitamin D deficiency is unclear. We hypothesized that changes in QT interval duration, which affect QT dispersion (QTd), mediate increased cardiac mortality in patients with vitamin D deficiency. This study aimed to evaluate the association between vitamin D, QTd, and the extent of CAD.

Methods

A total of 122 patients (56 women; mean age, 54.9 ± 9.3 years) were enrolled in this cross-sectional study. Levels of 25-hydroxyvitamin D (25[OH]D) and QTd were measured in all patients. The extent of CAD was evaluated by the Gensini score (GS). Patients were divided into two groups according to the median GS (group 1: GS <12 and group 2: GS ≥12). Levels of 25(OH)D and QTd were compared between the groups. Multivariate logistic regression analysis was used to identify the independent predictors of the severity of coronary atherosclerosis.

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