Objective
Patients with the coronary slow flow phenomenon frequently experience angina episodes. Given the underlying etiology of microvascular dysfunction in slow flow, anti-angina medications like nicorandil with vasodilatory effects on both large coronary arteries and small arterioles might be superior to nitroglycerin in amelioration of angina symptoms in this group of patients. The present study aimed to compare the efficacy of nicorandil versus nitroglycerin for alleviation of angina symptoms in slow flow patients.
Methods
In a single-center, single-blind, parallel-design, comparator-controlled, randomized clinical trial (NCT02254252), 54 patients with slow flow and normal or near-normal coronary angiography who presented with frequent angina episodes were randomly assigned to one month treatment with nicorandil 10mg two times a day (n=27) or sustained-release glyceryl trinitrate 6.4mg, two times a day (n=27). Frequency of angina episodes, pain intensity, and the Canadian Cardiovascular Society (CCS) grading of angina pectoris were assessed at baseline and after one month.
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