OP-049 A Novel Marker for Asymptomatic Organ Damage in the Patients with Hypertension: MIR-21




Objectives


Hypertension (HT) is a modifiable risk factor for cardiovascular, cerebrovascular, and renal disease. To be aware of asymptomatic organ damage (AOD) in hypertensive patients is important for HT management.We aimed to define the relation of plasma micro RNA-21 (miR-21), oxidized LDL (oxLDL) and the lectin-like oxLDL receptor (LOX-1) levels with the parameters those reflect AOD such as carotid intima media thickness (CIMT) in hypertensive patients compared to healthy controls. Moreover; to detect the relative increased levels of plasma miR-21 in patients with HT with respect to AOD.




Methods


The study population consisted of two groups: 32 hypertensive and 32 healthy controls were included. Firstly we compared these two groups. Then to signalize the relation of plasma miR-21 with HT; hypertensive patients were divided into two groups according to AOD as with AOD and without AOD.

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Nov 27, 2016 | Posted by in CARDIOLOGY | Comments Off on OP-049 A Novel Marker for Asymptomatic Organ Damage in the Patients with Hypertension: MIR-21

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