Objective

The aim of this study was to investigate the effects of Adducin Gly460Trp, and methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C gene polymorphisms which are supposed to play a role in atherothrombotic process in patients with peripheral arterial disease (PAD).

Patients and Methods

This prospective study was performed on a total of 270 participants between January 2013 and June 2014. The participants were divided into two groups: Group 1 (PAD group) included 180 patients with PAD (mean age: 55±18 years, 128 males), and Group 2 (control group) included 90 participants (mean age: 53±15 years, 61 males) with normal physical examination and arterial duplex ultrasonography findings for PAD. Groups were compared with each other according to the clinical and demographic characteristics, levels of some biochemical parameters, allele frequencies, and particularly Adducin Gly460Trp, MTHFR C677T and A1298C gene polymorphisms which determined by using real time polymerase chain reaction method.

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