Objective
Heart-type Fatty Acid Binding Protein (H-FABP), an early marker of cardiac necrosis, is a cytosolic protein of low molecular weight which is released rapidly from myocardium as a consequence of ischemic injury. We hypothesized that more severe and extensive coronary atherosclerosis would result in more pronounced myocardial injury and necrosis in patients with acute myocardial infarction (AMI). Therefore, we sought the relationship between serum H-FABP levels and the severity and extent of coronary artery disease (CAD) assessed using the Gensini score.
Methods
Fifty patients with AMI who underwent invasive coronary angiography were divided into 2 groups according to the angiographic Gensini score, namely the moderate to severe CAD group (Group 1, n=34) and the mild CAD group (Group 2, n=16). A point of care test was used to detect whether H-FABP was positive. Afterwards, the quantitative measurement of serum H-FABP concentrations were performed by using a Cardiodetect Quant device. The data obtained from this study were evaluated using the PASW statistic prrogramme.
Methods
Fifty patients with AMI who underwent invasive coronary angiography were divided into 2 groups according to the angiographic Gensini score, namely the moderate to severe CAD group (Group 1, n=34) and the mild CAD group (Group 2, n=16). A point of care test was used to detect whether H-FABP was positive. Afterwards, the quantitative measurement of serum H-FABP concentrations were performed by using a Cardiodetect Quant device. The data obtained from this study were evaluated using the PASW statistic prrogramme.
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