Objective
The development of left ventricular remodeling after acute myocardial infarction is a predictor of heart failure, shock and mortality. However, the genetic influence on cardiac remodeling, and shock in the early period after acute myocardial infarction are unclear. The aim of the present study was to investigate the relationship between angiotensin-II type-1 receptor (AT1R) gene polymorphism and shock index in the early period in patients with acute anterior myocardial infarction (AMI).
Material-Methods
The subjects were 132 patients (106 men, 26 women, 59 ± 12 years) with a first anterior AMI. Based on the polymorphism of the AT1R gene, they were classified into two groups: Group 1(AA genotype) of 91 patients and group 2 (AC and CC genotype) of 41 patients (Figure 1). Blood pressure and pulse measurements were performed in all patients within 10 minutes admitted to coronary care unit. The Shock Index (SI) was calculated for each individual patient by the ratio of HR to SBP. Echocardiographic examinations were performed using the parasternal longitudinal axis and apical 4-chamber windows in accordance with the recommendations of the American Echocardiography Committee. One-way analysis of variance (ANOVA) and Chi-square analyses were used to compare differences among subjects with different genotypes.
Material-Methods
The subjects were 132 patients (106 men, 26 women, 59 ± 12 years) with a first anterior AMI. Based on the polymorphism of the AT1R gene, they were classified into two groups: Group 1(AA genotype) of 91 patients and group 2 (AC and CC genotype) of 41 patients (Figure 1). Blood pressure and pulse measurements were performed in all patients within 10 minutes admitted to coronary care unit. The Shock Index (SI) was calculated for each individual patient by the ratio of HR to SBP. Echocardiographic examinations were performed using the parasternal longitudinal axis and apical 4-chamber windows in accordance with the recommendations of the American Echocardiography Committee. One-way analysis of variance (ANOVA) and Chi-square analyses were used to compare differences among subjects with different genotypes.
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