Objectives
The development of left ventricular remodeling after acute myocardial infarction is a predictor of heart failure, shock and mortality. However, the genetic influence on cardiac remodeling, and shock in the early period after acute myocardial infarction are unclear. The aim of the present study was to investigate the relationship between angiotensin converting enzyme (ACE) gene polymorphism and shock index in the early period in patients with acute anterior myocardial infarction (AMI).
Methods
Overall 140 patients with a first acute AMI were included in this cross-sectional study. DNA was isolated from peripheral leukocytes. The ID status was determined by polymerase chain reaction by a laboratory staff member who was unaware of the clinical details. Based on the polymorphism of the ACE gene, they were classified into 2 groups: Deletion / Deletion (DD) genotype (Group 1, n=57), Insertion / Deletion (ID), Insertion / Insertion (II) genotypes (Group 2, n=83) (Figure 1). Blood pressure and pulse measurements were performed in all patients within 10 minutes admitted to coronary care unit. The Shock Index (SI) was calculated for each individual patient by the ratio of HR to SBP. Echocardiographic examinations were performed using the parasternal longitudinal axis and apical 4-chamber windows in accordance with the recommendations of the American Echocardiography Committee. One-way analysis of variance (ANOVA) and Chi-square analyses were used to compare differences among subjects with different genotypes.
Methods
Overall 140 patients with a first acute AMI were included in this cross-sectional study. DNA was isolated from peripheral leukocytes. The ID status was determined by polymerase chain reaction by a laboratory staff member who was unaware of the clinical details. Based on the polymorphism of the ACE gene, they were classified into 2 groups: Deletion / Deletion (DD) genotype (Group 1, n=57), Insertion / Deletion (ID), Insertion / Insertion (II) genotypes (Group 2, n=83) (Figure 1). Blood pressure and pulse measurements were performed in all patients within 10 minutes admitted to coronary care unit. The Shock Index (SI) was calculated for each individual patient by the ratio of HR to SBP. Echocardiographic examinations were performed using the parasternal longitudinal axis and apical 4-chamber windows in accordance with the recommendations of the American Echocardiography Committee. One-way analysis of variance (ANOVA) and Chi-square analyses were used to compare differences among subjects with different genotypes.
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